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    klhl24b kelch-like family member 24b [ Danio rerio (zebrafish) ]

    Gene ID: 393412, updated on 28-Oct-2024

    Summary

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    Official Symbol
    klhl24bprovided by ZNC
    Official Full Name
    kelch-like family member 24bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1185
    See related
    AllianceGenome:ZFIN:ZDB-GENE-040426-1185
    Gene type
    protein coding
    RefSeq status
    PREDICTED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:eu993; zgc:63606
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within regulation of kainate selective glutamate receptor activity. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex and familial hypertrophic cardiomyopathy. Orthologous to human KLHL24 (kelch like family member 24). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See klhl24b in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (25761908..25788841, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (25616867..25643800, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 2 Neighboring gene uncharacterized LOC137489248 Neighboring gene SH3-domain kinase binding protein 1 Neighboring gene mitogen-activated protein kinase kinase kinase 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cardiomyopathy with lethal arrhythmias associated with inactivation of KLHL24. Hedberg-Oldfors C, et al. Hum Mol Genet, 2019 Jun 1. PMID 30715372, Free PMC Article
    2. Saltatory evolution of the ectodermal neural cortex gene family at the vertebrate origin. Feiner N, et al. Genome Biol Evol, 2013. PMID 23843192, Free PMC Article
    3. Unilateral dampening of Bmp activity by nodal generates cardiac left-right asymmetry. Veerkamp J, et al. Dev Cell, 2013 Mar 25. PMID 23499359
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC63606

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of kainate selective glutamate receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC393412
    Names
    kelch-like 24b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200440.1 → NP_956734.1  uncharacterized protein LOC393412

      See identical proteins and their annotated locations for NP_956734.1

      Status: PREDICTED

      Source sequence(s)
      BC054921
      UniProtKB/TrEMBL
      Q7SYC4
      Conserved Domains (4) summary
      smart00612
      Location:314 → 363
      Kelch; Kelch domain
      smart00225
      Location:67 → 163
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:56 → 159
      BTB; BTB/POZ domain
      pfam07707
      Location:168 → 270
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      25761908..25788841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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