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    IRSp53 Insulin receptor substrate 53 kDa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39258, updated on 2-Nov-2024

    Summary

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    Official Symbol
    IRSp53provided by FlyBase
    Official Full Name
    Insulin receptor substrate 53 kDaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052082
    Locus tag
    Dmel_CG32082
    See related
    AllianceGenome:FB:FBgn0052082
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.199; CG32082; CG7624; Dmel\CG32082; IRS
    Summary
    Predicted to enable phospholipid binding activity. Involved in filopodium assembly. Predicted to be active in cytosol and nucleoplasm. Is expressed in adult head. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and autism spectrum disorder. Orthologous to several human genes including BAIAP2 (BAR/IMD domain containing adaptor protein 2) and BAIAP2L1 (BAR/IMD domain containing adaptor protein 2 like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See IRSp53 in Genome Data Viewer
    Location:
    68A8-68A9; 3-34 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11136049..11163984)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11129149..11157084)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Na[+]-dependent inorganic phosphate cotransporter type III Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43989 Neighboring gene ALG10 alpha-1,2-glucosyltransferase Neighboring gene wntless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adhesion and Fusion of Muscle Cells Are Promoted by Filopodia. Segal D, et al. Dev Cell, 2016 Aug 8. PMID 27505416
    2. LTR-mediated retroposition as a mechanism of RNA-based duplication in metazoans. Tan S, et al. Genome Res, 2016 Dec. PMID 27934698, Free PMC Article
    3. Genome-Wide Association Analysis of Anoxia Tolerance in Drosophila melanogaster. Campbell JB, et al. G3 (Bethesda), 2019 Sep 4. PMID 31311780, Free PMC Article
    4. An actomyosin clamp assembled by the Amphiphysin-Rho1-Dia/DAAM-Rok pathway reinforces somatic cell membrane folded around spermatid heads. Kapoor T, et al. Cell Rep, 2021 Mar 30. PMID 33789114
    5. Drosophila as a model system for deciphering the 'host physiology-nutrition-microbiome' axis. Lee JH, et al. Curr Opin Insect Sci, 2020 Oct. PMID 32979529

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    insulin receptor substrate 53 kDa
    Names
    CG32082-PA
    CG32082-PB
    CG32082-PD
    CG32082-PE
    IRSp53-PA
    IRSp53-PB
    IRSp53-PD
    IRSp53-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11136049..11163984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168448.3 → NP_729679.2  insulin receptor substrate 53 kDa, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729679.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQE6
      Conserved Domains (2) summary
      cd07605
      Location:4 → 222
      I-BAR_IMD; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), a dimerization module that binds and bends membranes
      cd11779
      Location:364 → 419
      SH3_Irsp53_BAIAP2L; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53, Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2 (BAIAP2)-Like proteins, and similar proteins

    2. NM_001104112.2 → NP_001097582.1  insulin receptor substrate 53 kDa, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097582.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNR3
      Conserved Domains (2) summary
      cd07605
      Location:4 → 222
      I-BAR_IMD; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), a dimerization module that binds and bends membranes
      cd11779
      Location:364 → 419
      SH3_Irsp53_BAIAP2L; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53, Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2 (BAIAP2)-Like proteins, and similar proteins

    3. NM_001104113.2 → NP_001097583.2  insulin receptor substrate 53 kDa, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097583.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNR2
      Conserved Domains (2) summary
      cd07605
      Location:4 → 222
      I-BAR_IMD; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), a dimerization module that binds and bends membranes
      cd11779
      Location:364 → 419
      SH3_Irsp53_BAIAP2L; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53, Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2 (BAIAP2)-Like proteins, and similar proteins

    4. NM_001300098.1 → NP_001287027.1  insulin receptor substrate 53 kDa, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287027.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCT5
      Conserved Domains (2) summary
      cd07605
      Location:4 → 222
      I-BAR_IMD; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), a dimerization module that binds and bends membranes
      cd11779
      Location:364 → 419
      SH3_Irsp53_BAIAP2L; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53, Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2 (BAIAP2)-Like proteins, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNR2 A8JNR2
    A8JNR3 A8JNR3
    Q8IQE6 Q8IQE6
    X2JCT5 X2JCT5

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