JIL-1 JIL-1 kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: JIL-1provided by FlyBase
Official Full Name: JIL-1 kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0020412
Locus tag: Dmel_CG6297
See related: AllianceGenome:FB:FBgn0020412
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2Ab17; anon-WO0118547.379; CG6297; Dmel\CG6297; IL-1; JIL; jil-1; Jil-1; JiL-1; Jil1; JIL1; mAb2A; MSK; MSK1; Su(var)3-1; Su(var)3-103; Su-var(3)1; Su-var(3)103
Summary: Enables histone H3S10 kinase activity. Involved in several processes, including heterochromatin boundary formation; protein autophosphorylation; and telomere maintenance. Located in chromosome. Part of X chromosome located dosage compensation complex, transcription activating. Is expressed in adult brain cell body rind. Orthologous to several human genes including RPS6KA5 (ribosomal protein S6 kinase A5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 68A5-68A6; 3-34 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (11078752..11093193, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (11071852..11086293, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that JIL-1 kinase (JIL-1) not only prevents heterochromatin formation but also coordinates chromatin-based regulation in the transcribed part of the genome.
Title: JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila.
our data indicate that the conserved H3S28 residue in metazoans has a role in supporting PRC2 catalysis.
Title: Histone H3 Serine 28 Is Essential for Efficient Polycomb-Mediated Gene Repression in Drosophila.
results strongly suggest that the action of JIL-1 depends on which telomere domain, which chromosome and which promoter is embedded in the telomere chromatin.
Title: The JIL-1 kinase affects telomere expression in the different telomere domains of Drosophila.
JIL-1 regulated heterochromatin in the context of the chromocenter and fourth chromosome by creating a composite H3S10phK9me2 mark together with the Su(var)3-9 methyltransferase.
Title: Histone H3S10 phosphorylation by the JIL-1 kinase in pericentric heterochromatin and on the fourth chromosome creates a composite H3S10phK9me2 epigenetic mark.
Enrichment of JIL-1 and the H3S10ph mark are predominantly associated with active genes in Drosophila.
Title: Genome-wide analysis of regulation of gene expression and H3K9me2 distribution by JIL-1 kinase mediated histone H3S10 phosphorylation in Drosophila.
The results suggest that JIL-1 is not a histone H3S28 kinase and that it is not involved in 14-3-3 recruitment in Drosophila.
Title: Evidence against a role for the JIL-1 kinase in H3S28 phosphorylation and 14-3-3 recruitment to active genes in Drosophila.
epigenetic H3S10 phosphorylation mark itself functions as a causative regulator of chromatin structure independently of any structural contributions from the JIL-1 protein.
Title: Domain requirements of the JIL-1 tandem kinase for histone H3 serine 10 phosphorylation and chromatin remodeling in vivo.
JIL-1 and Z4 (also known as Putzig), which are necessary for establishing a fine-tuned regulation of the transcription of the major component of Drosophila telomeres, the HeT-A retrotransposon, thus guaranteeing genome stability
Title: The chromosomal proteins JIL-1 and Z4/Putzig regulate the telomeric chromatin in Drosophila melanogaster.
JIL-1 and phosphoacetylated H3 histone are found at enhancers genome-wide prior to activation of transcription
Title: Genome-wide phosphoacetylation of histone H3 at Drosophila enhancers and promoters.
JIL-1 loss-of-function alleles can act either as an enhancer or indirectly as a suppressor of w(m4) position-effect variegation depending on the precise levels of JIL-1 kinase activity.
Title: H3S10 phosphorylation by the JIL-1 kinase regulates H3K9 dimethylation and gene expression at the white locus in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c11088845-11087112 mobile_element_type = transposon:S{}977

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin boundary formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-translational protein modification	IDA Inferred from Direct Assay more info	PubMed
involved_in post-translational protein modification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of X chromosome located dosage compensation complex, transcription activating	IPI Inferred from Physical Interaction more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome interband	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: JIL-1 kinase

Names: CG6297-PA; CG6297-PB; CG6297-PC; JIL-1 histone H3S10 kinase; JIL-1 histone kinase; JIL-1-PA; JIL-1-PB; JIL-1-PC; suppressor of variegation 3-1

NP_001261697.1

EC 2.7.11.1

NP_648432.1

EC 2.7.11.1

NP_729661.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

11078752..11093193 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274768.1 → NP_001261697.1 JIL-1 kinase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261697.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B5RJL0, Q0E8F9, Q95RY3, Q9V3I5

UniProtKB/TrEMBL

I1V4Y5, M9PI05

Conserved Domains (4) summary

smart00133
Location:532 → 591

S_TK_X; Extension to Ser/Thr-type protein kinases

smart00220
Location:261 → 530

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05583
Location:266 → 533

STKc_MSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase

cl21453
Location:632 → 885

PKc_like; Protein Kinases, catalytic domain
NM_168439.2 → NP_729661.1 JIL-1 kinase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729661.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B5RJL0, Q0E8F9, Q95RY3, Q9V3I5

UniProtKB/TrEMBL

I1V4Y5, M9PI05

Related

FBpp0075966

Conserved Domains (4) summary

smart00133
Location:532 → 591

S_TK_X; Extension to Ser/Thr-type protein kinases

smart00220
Location:261 → 530

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05583
Location:266 → 533

STKc_MSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase

cl21453
Location:632 → 885

PKc_like; Protein Kinases, catalytic domain
NM_140175.3 → NP_648432.1 JIL-1 kinase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648432.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B5RJL0, Q0E8F9, Q95RY3, Q9V3I5

UniProtKB/TrEMBL

I1V4Y5, M9PI05

Related

FBpp0075965

Conserved Domains (4) summary

smart00133
Location:532 → 591

S_TK_X; Extension to Ser/Thr-type protein kinases

smart00220
Location:261 → 530

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05583
Location:266 → 533

STKc_MSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase

cl21453
Location:632 → 885

PKc_like; Protein Kinases, catalytic domain