Klp67A Kinesin-like protein at 67A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Klp67Aprovided by FlyBase
Official Full Name: Kinesin-like protein at 67Aprovided by FlyBase
Primary source: FLYBASE:FBgn0004379
Locus tag: Dmel_CG10923
See related: AllianceGenome:FB:FBgn0004379
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0427/05; anon-WO0140519.224; anon-WO0172774.120; CG10923; Dmel\CG10923; DmKlp67A; KIF 18A; KIF18A/B; Kin-8; Klp3; KLP3; klp67; Klp67; klp67a; klp67A; KLP67A; KRP67A; l(3)S042705
Summary: Enables cytoskeletal motor activity. Involved in several processes, including generative cell mitosis; microtubule cytoskeleton organization; and nuclear chromosome segregation. Located in several cellular components, including kinetochore; nucleus; and spindle. Part of microtubule associated complex. Is expressed in several structures, including CNS glial cell; central brain primordium; cuboidal/columnar epithelium; ganglia; and gonad. Orthologous to several human genes including KIF18A (kinesin family member 18A). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: 67B2-67B2; 3-29 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9362636..9367046, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9355736..9360146, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results suggest that the MT-stabilizing activity of kinesin-8 is critical for stable kinetochore-MT attachment.
Title: Drosophila kinesin-8 stabilizes the kinetochore-microtubule interaction.
Results suggest that KLP67A plays an important role in controlling the dynamics of microtubule (MT) plus ends to limit MT polymerization thereby preventing the plus ends from extending far enough to reach the opposite pole.
Title: Coupling between microtubule sliding, plus-end growth and spindle length revealed by kinesin-8 depletion.
The data reveal that, unlike other metazoan kinesin-8 proteins, Klp67A binds the nascent prophase and mature metaphase kinetochore. From this location, Klp67A uses its motor activity to ensure chromosome alignment and proper spindle length.
Title: Drosophila Klp67A binds prophase kinetochores to subsequently regulate congression and spindle length.
KLP67A is essential for spindle assembly during mitosis and male meiosis
Title: The Drosophila kinesin-like protein KLP67A is essential for mitotic and male meiotic spindle assembly.
Klp67A is a member of the Kip3 subfamily of microtubule destabilising kinesins, the loss of which results in abnormally long and stable pre-anaphase microtubules
Title: Klp67A destabilises pre-anaphase microtubules but subsequently is required to stabilise the central spindle.
Hypomorphic mutations of klp67A may lead to segregation defects
Title: Drosophila Klp67A is required for proper chromosome congression and segregation during meiosis I.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal motor activity	IDA Inferred from Direct Assay more info	PubMed
enables cytoskeletal motor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in generative cell mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiotic chromosome movement towards spindle pole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiosis I cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic centrosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sister chromatid biorientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle assembly involved in male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle elongation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	TAS Traceable Author Statement more info	PubMed
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore microtubule	IDA Inferred from Direct Assay more info	PubMed
part_of microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle astral microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitotic spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in spindle microtubule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Kinesin-like protein at 67A

Names: CG10923-PA; CG10923-PB; CG10923-PC; Kinesin-8; Kinesin8A; Klp67A-PA; Klp67A-PB; Klp67A-PC; kinesin 8; kinesin like protein 67a; lethal (3) S042705

NP_001261624.1

EC 5.6.1.3

NP_001286999.1

EC 5.6.1.3

NP_523992.2

EC 5.6.1.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9362636..9367046 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300070.1 → NP_001286999.1 Kinesin-like protein at 67A, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286999.1

Status: REVIEWED

UniProtKB/TrEMBL

P91945, Q9VSW5

Conserved Domains (2) summary

smart00129
Location:8 → 353

KISc; Kinesin motor, catalytic domain. ATPase

cd01370
Location:8 → 346

KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
NM_079268.3 → NP_523992.2 Kinesin-like protein at 67A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523992.2

Status: REVIEWED

UniProtKB/TrEMBL

P91945, Q9VSW5

Related

FBpp0076227

Conserved Domains (2) summary

smart00129
Location:8 → 353

KISc; Kinesin motor, catalytic domain. ATPase

cd01370
Location:8 → 346

KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
NM_001274695.1 → NP_001261624.1 Kinesin-like protein at 67A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261624.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PF35, P91945

Conserved Domains (2) summary

smart00129
Location:8 → 353

KISc; Kinesin motor, catalytic domain. ATPase

cd01370
Location:8 → 346

KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup