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    sphinx2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38833, updated on 22-Aug-2024

    Summary

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    Official Symbol
    sphinx2provided by FlyBase
    Primary source
    FLYBASE:FBgn0052382
    Locus tag
    Dmel_CG32382
    See related
    AllianceGenome:FB:FBgn0052382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32382; CG8555; Dmel\CG32382; SPH194; SPH194b; sphinx-2; Sphinx2; Spx2
    Summary
    Involved in defense response to other organism; multicellular organism reproduction; and positive regulation of Toll signaling pathway. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See sphinx2 in Genome Data Viewer
    Location:
    66A1-66A1; 3-21 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7439554..7440733, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7432799..7433833, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene sphinx1 Neighboring gene uncharacterized protein Neighboring gene pickpocket 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila melanogaster seminal fluid protease "seminase" regulates proteolytic and post-mating reproductive processes. LaFlamme BA, et al. PLoS Genet, 2012 Jan. PMID 22253601, Free PMC Article
    2. Protease gene duplication and proteolytic activity in Drosophila female reproductive tracts. Kelleher ES, et al. Mol Biol Evol, 2009 Sep. PMID 19546158, Free PMC Article
    3. Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation. Kambris Z, et al. Curr Biol, 2006 Apr 18. PMID 16631589
    4. The Drosophila Toll signaling pathway. Valanne S, et al. J Immunol, 2011 Jan 15. PMID 21209287
    5. Identification and function of proteolysis regulators in seminal fluid. Laflamme BA, et al. Mol Reprod Dev, 2013 Feb. PMID 23109270, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Toll receptor ligand protein activation cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sphinx2
    Names
    CG32382-PB
    CG32382-PC
    Sphinx2
    sphinx2-PB
    sphinx2-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7439554..7440733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316479.1 → NP_001303408.1  sphinx2, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V4Q2, Q9VS71
      Conserved Domains (2) summary
      smart00020
      Location:25 → 245
      Tryp_SPc; Trypsin-like serine protease
      cl21584
      Location:26 → 248
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_168215.2 → NP_729256.2  sphinx2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729256.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V4Q2, Q9VS71
      Conserved Domains (2) summary
      smart00020
      Location:25 → 245
      Tryp_SPc; Trypsin-like serine protease
      cl21584
      Location:26 → 248
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VS71 Q9VS71

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