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    Lcp65Ac [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38708, updated on 22-Aug-2024

    Summary

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    Official Symbol
    Lcp65Acprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020642
    Locus tag
    Dmel_CG6956
    See related
    AllianceGenome:FB:FBgn0020642
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6956; DCP2; Dmel\CG6956; DMLCP65c; Lcp-c; LCP65Ac
    Summary
    Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic esophagus and embryonic head epidermis. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    Location:
    65A6-65A6; 3-16 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6144819..6145393)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6137919..6138493)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 65Aw Neighboring gene Lcp65Ad Neighboring gene Lcp65Ab2 Neighboring gene Cuticular protein 65Ax1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Is beta-pleated sheet the molecular conformation which dictates formation of helicoidal cuticle? Iconomidou VA, et al. Insect Biochem Mol Biol, 1999 Mar. PMID 10319442
    2. A cluster of cuticle protein genes of Drosophila melanogaster at 65A: sequence, structure and evolution. Charles JP, et al. Genetics, 1997 Nov. PMID 9383064, Free PMC Article
    3. Identification of proteins and developmental expression of RNAs encoded by the 65A cuticle protein gene cluster in Drosophila melanogaster. Charles JP, et al. Insect Biochem Mol Biol, 1998 Mar. PMID 9654737
    4. A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis. Pandey V, et al. Front Cell Neurosci, 2013. PMID 24058333, Free PMC Article
    5. Systematic imaging reveals features and changing localization of mRNAs in Drosophila development. Jambor H, et al. Elife, 2015 Apr 2. PMID 25838129, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chitin-based larval cuticle ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables structural constituent of chitin-based larval cuticle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chitin-based extracellular matrix ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Lcp65Ac
    Names
    CG6956-PA
    Lcp65Ac-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6144819..6145393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057931.5 → NP_477279.1  Lcp65Ac [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477279.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P92181
      Related
      FBpp0076700
      Conserved Domains (1) summary
      pfam00379
      Location:40 → 95
      Chitin_bind_4; Insect cuticle protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P92181 P92181

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