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    Ccz1 Caffeine, calcium, zinc sensitivity 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38455, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ccz1provided by FlyBase
    Official Full Name
    Caffeine, calcium, zinc sensitivity 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035470
    Locus tag
    Dmel_CG14980
    See related
    AllianceGenome:FB:FBgn0035470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    C7orf28B; CCZ1; CG14980; Dccz1; Dmel\CG14980; NP_647835
    Summary
    Contributes to guanyl-nucleotide exchange factor activity. Involved in endosome to lysosome transport via multivesicular body sorting pathway. Located in cytosol. Part of Mon1-Ccz1 complex. Is expressed in adult head and organism. Orthologous to human CCZ1B (CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated) and CCZ1 (CCZ1 homolog, vacuolar protein trafficking and biogenesis associated). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Ccz1 in Genome Data Viewer
    Location:
    63F5-63F5; 3-9 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3897444..3899156, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3897444..3899156, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene small nuclear RNA U11 Neighboring gene Fire exit Neighboring gene Gustatory receptor 63a Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Neighboring gene Ubiquitin-63E Neighboring gene Sc2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cryo-EM structure of the Mon1-Ccz1-RMC1 complex reveals molecular basis of metazoan RAB7A activation. Yong X, et al. Proc Natl Acad Sci U S A, 2023 May 30. PMID 37216550, Free PMC Article
    2. A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function. Dehnen L, et al. J Cell Sci, 2020 Jul 9. PMID 32499409
    3. Regulatory sites in the Mon1-Ccz1 complex control Rab5 to Rab7 transition and endosome maturation. Borchers AC, et al. Proc Natl Acad Sci U S A, 2023 Jul 25. PMID 37463208, Free PMC Article
    4. Endosomal recycling protein Rab11 in Parkin and Pink1 signaling in Drosophila model of Parkinson's disease. Rai P, et al. Exp Cell Res, 2022 Nov 15. PMID 36116557
    5. A conserved and regulated mechanism drives endosomal Rab transition. Langemeyer L, et al. Elife, 2020 May 11. PMID 32391792, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endosome to lysosome transport via multivesicular body sorting pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Mon1-Ccz1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Mon1-Ccz1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of Mon1-Ccz1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Caffeine, calcium, zinc sensitivity 1
    Names
    CG14980-PB
    Ccz1 ortholog
    Ccz1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3897444..3899156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139578.3 → NP_647835.1  Caffeine, calcium, zinc sensitivity 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647835.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYB1, Q9VZL5
      Related
      FBpp0073036
      Conserved Domains (1) summary
      pfam08217
      Location:15 → 482
      DUF1712; Fungal domain of unknown function (DUF1712)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZL5 Q9VZL5
    Q9VZL5.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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