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    Pgant6 Polypeptide N-Acetylgalactosaminyltransferase 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38346, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Pgant6provided by FlyBase
    Official Full Name
    Polypeptide N-Acetylgalactosaminyltransferase 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0035375
    Locus tag
    Dmel_CG2103
    See related
    AllianceGenome:FB:FBgn0035375
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2103; Dmel\CG2103; pgant6
    Summary
    Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in oligosaccharide biosynthetic process. Located in endoplasmic reticulum. Is expressed in several structures, including antenno-maxillary complex; embryonic/larval midgut primordium; gut section; hindgut proper primordium; and imaginal disc. Orthologous to several human genes including GALNTL6 (polypeptide N-acetylgalactosaminyltransferase like 6). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Pgant6 in Genome Data Viewer
    Location:
    62F4-62F4; 3-4 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2782255..2786010)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2782255..2786010)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Autophagy-related 2 Neighboring gene mitochondrial ribosomal protein S35 Neighboring gene Ten-Eleven Translocation (TET) family protein Neighboring gene long non-coding RNA:CR44531

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family is spatially and temporally regulated during Drosophila development. Tian E, et al. Glycobiology, 2006 Feb. PMID 16251381
    2. Functional characterization and expression analysis of members of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family from Drosophila melanogaster. Ten Hagen KG, et al. J Biol Chem, 2003 Sep 12. PMID 12829714
    3. Multiple members of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family are essential for viability in Drosophila. Tran DT, et al. J Biol Chem, 2012 Feb 17. PMID 22157008, Free PMC Article
    4. Cisterna-specific localization of glycosylation-related proteins to the Golgi apparatus. Yamamoto-Hino M, et al. Cell Struct Funct, 2012. PMID 22251795
    5. Dissecting the biological role of mucin-type O-glycosylation using RNA interference in Drosophila cell culture. Zhang L, et al. J Biol Chem, 2010 Nov 5. PMID 20807760, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi stack NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polypeptide N-Acetylgalactosaminyltransferase 6
    Names
    CG2103-PA
    CG2103-PB
    CG2103-PC
    Pgant6-PA
    Pgant6-PB
    Pgant6-PC
    polypeptide GalNAc transferase 6
    NP_001261342.1
    NP_647749.2
    NP_728779.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2782255..2786010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167966.2 → NP_728779.1  polypeptide N-Acetylgalactosaminyltransferase 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728779.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8I9, Q6WV16, Q95R40, Q9VZX5
      UniProtKB/TrEMBL
      M9PBK1
      Related
      FBpp0072843
      Conserved Domains (4) summary
      cd02510
      Location:205 → 502
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG1215
      Location:199 → 413
      BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]
      cd00161
      Location:520 → 647
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:520 → 645
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. NM_001274413.1 → NP_001261342.1  polypeptide N-Acetylgalactosaminyltransferase 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261342.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8I9, Q6WV16, Q95R40, Q9VZX5
      UniProtKB/TrEMBL
      M9PBK1
      Conserved Domains (4) summary
      cd02510
      Location:205 → 502
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG1215
      Location:199 → 413
      BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]
      cd00161
      Location:520 → 647
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:520 → 645
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    3. NM_139492.3 → NP_647749.2  polypeptide N-Acetylgalactosaminyltransferase 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647749.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8I9, Q6WV16, Q95R40, Q9VZX5
      UniProtKB/TrEMBL
      M9PBK1
      Related
      FBpp0072842
      Conserved Domains (4) summary
      cd02510
      Location:205 → 502
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG1215
      Location:199 → 413
      BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]
      cd00161
      Location:520 → 647
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:520 → 645
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBK1 M9PBK1
    Q6WV16.2 Q6WV16

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