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    CG7970 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38205, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CG7970provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035252
    Locus tag
    Dmel_CG7970
    See related
    AllianceGenome:FB:FBgn0035252
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.268; Dmel\CG7970
    Summary
    Predicted to enable monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in peroxisomal membrane. Is expressed in several structures, including adult head; adult heart; anterior endoderm; gut section; and mesoderm. Orthologous to human PXMP2 (peroxisomal membrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See CG7970 in Genome Data Viewer
    Location:
    62A10-62A10; 3-0.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1652750..1654238)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1653005..1654112)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45815 Neighboring gene uncharacterized protein Neighboring gene Brother Neighboring gene Vesicle trafficking 1 Neighboring gene Serine-arginine repetitive matrix 2/3/4 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L23A Neighboring gene U snoRNA host gene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila model of the neurological symptoms in Mpv17-related diseases. Kodani A, et al. Sci Rep, 2022 Dec 31. PMID 36587049, Free PMC Article
    2. Drosophila Mpv17 forms an ion channel and regulates energy metabolism. Corrà S, et al. iScience, 2023 Oct 20. PMID 37810222, Free PMC Article
    3. Green fluorescent protein tagging Drosophila proteins at their native genomic loci with small P elements. Clyne PJ, et al. Genetics, 2003 Nov. PMID 14668392, Free PMC Article
    4. Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila. Blard O, et al. Hum Mol Genet, 2007 Mar 1. PMID 17309878
    5. Genetic Basis of Increased Lifespan and Postponed Senescence in Drosophila melanogaster. Parker GA, et al. G3 (Bethesda), 2020 Mar 5. PMID 31969430, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7970-PA
    CG7970-PB
    CG7970-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1652750..1654238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316449.1 → NP_001303378.1  uncharacterized protein Dmel_CG7970, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0WGR0
      Conserved Domains (1) summary
      pfam04117
      Location:178 → 238
      Mpv17_PMP22; Mpv17 / PMP22 family

    2. NM_001274343.1 → NP_001261272.1  uncharacterized protein Dmel_CG7970, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261272.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0B2
      Conserved Domains (1) summary
      pfam04117
      Location:114 → 174
      Mpv17_PMP22; Mpv17 / PMP22 family

    3. NM_139384.3 → NP_647641.1  uncharacterized protein Dmel_CG7970, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647641.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0B2
      Related
      FBpp0072645
      Conserved Domains (1) summary
      pfam04117
      Location:114 → 174
      Mpv17_PMP22; Mpv17 / PMP22 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0WGR0 A0A0S0WGR0
    Q9W0B2 Q9W0B2

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