U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Snap29 Synaptosomal-associated protein 29kDa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37774, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Snap29provided by FlyBase
    Official Full Name
    Synaptosomal-associated protein 29kDaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034913
    Locus tag
    Dmel_CG11173
    See related
    AllianceGenome:FB:FBgn0034913
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11173; Dmel\CG11173; dSNAP-29; MENE (2R)-E; MENE(2R)-E; SNAP-29; snap29; SNAP29; ubisnap; Ubisnap; usnp; Usnp
    Summary
    Enables SNAP receptor activity and SNARE binding activity. Involved in several processes, including T-tubule organization; autophagosome maturation; and secretory granule-lysosome fusion. Part of SNARE complex. Is expressed in several structures, including adult head; embryonic/larval garland cell; garland cell primordium; and imaginal disc. Used to study CEDNIK syndrome. Human ortholog(s) of this gene implicated in CEDNIK syndrome. Orthologous to human SNAP29 (synaptosome associated protein 29). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Snap29 in Genome Data Viewer
    Location:
    60A3-60A3; 2-105 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23843483..23844763, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19731006..19732286, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44805 Neighboring gene uncharacterized protein Neighboring gene shutdown Neighboring gene uncharacterized protein Neighboring gene yantar Neighboring gene eukaryotic translation initiation factor 6

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Evolutionarily conserved role and physiological relevance of a STX17/Syx17 (syntaxin 17)-containing SNARE complex in autophagosome fusion with endosomes and lysosomes. Hegedűs K, et al. Autophagy, 2013 Oct. PMID 24113031
    2. The Ykt6-Snap29-Syx13 SNARE complex promotes crinophagy via secretory granule fusion with Lamp1 carrier vesicles. Szenci G, et al. Sci Rep, 2024 Feb 8. PMID 38331993, Free PMC Article
    3. The multi-functional SNARE protein Ykt6 in autophagosomal fusion processes. Kriegenburg F, et al. Cell Cycle, 2019 Mar-Apr. PMID 30836834, Free PMC Article
    4. SNAP-24, a Drosophila SNAP-25 homologue on granule membranes, is a putative mediator of secretion and granule-granule fusion in salivary glands. Niemeyer BA, et al. J Cell Sci, 2000 Nov. PMID 11058092
    5. STING controls energy stress-induced autophagy and energy metabolism via STX17. Rong Y, et al. J Cell Biol, 2022 Jul 4. PMID 35510944, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here, we identify a novel role for Snap29, an unconventional SNARE, in promoting kinetochore assembly during mitosis in Drosophila and human cells. Snap29 localizes to the outer kinetochore and prevents chromosome mis-segregation and the formation of cells with fragmented nuclei.
      Title: An essential step of kinetochore formation controlled by the SNARE protein Snap29.
    2. SNAP-29 mediates an essential process in Drosophila development
      Title: Drosophila SNAP-29 is an essential SNARE that binds multiple proteins involved in membrane traffic.
    3. support a role of Snap29 at key steps of membrane trafficking, and predict that signaling defects may contribute to the pathogenesis of cerebral dysgenesis
      Title: Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila.
    4. Syntaxin17 is recruited to the outer membrane of autophagosomes to mediate fusion through its interactions with ubisnap (SNAP-29) and VAMP7 in Drosophila melanogaster
      Title: Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SNAP receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables SNARE binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in T-tubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of secretion by cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in secretory granule-lysosome fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SNARE complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Synaptosomal-associated protein 29kDa
    Names
    CG11173-PA
    Snap29-PA
    ubisnap

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23843483..23844763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079107.4 → NP_523831.1  Synaptosomal-associated protein 29kDa [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523831.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1I8
      Related
      FBpp0072145
      Conserved Domains (2) summary
      cd15856
      Location:222 → 280
      SNARE_SNAP29C; C-terminal SNARE motif of SNAP29
      cd15887
      Location:72 → 136
      SNARE_SNAP29N; N-terminal SNARE motif of SNAP29
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1I8 Q9W1I8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous