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    CG30269 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37600, updated on 22-Aug-2024

    Summary

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    Official Symbol
    CG30269provided by FlyBase
    Primary source
    FLYBASE:FBgn0050269
    Locus tag
    Dmel_CG30269
    See related
    AllianceGenome:FB:FBgn0050269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13515; Dmel\CG30269
    Summary
    Is expressed in embryonic Malpighian tubule; embryonic hindgut; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1C. Orthologous to human LITAF (lipopolysaccharide induced TNF factor). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG30269 in Genome Data Viewer
    Location:
    58F4-58F6; 2-100 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22667155..22668848)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18555444..18556353)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45269 Neighboring gene long non-coding RNA:CR42868 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ring and YY1 Binding Protein Neighboring gene long non-coding RNA:CR44761

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel. Gaspar CJ, et al. EMBO Rep, 2022 Jan 5. PMID 34918864, Free PMC Article
    2. Active promoters and insulators are marked by the centrosomal protein 190. Bartkuhn M, et al. EMBO J, 2009 Apr 8. PMID 19229299, Free PMC Article
    3. Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution. Ponting CP, et al. Genome Res, 2001 Dec. PMID 11731489
    4. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG30269-PA
    CG30269-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22667155..22668848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316431.1 → NP_001303360.1  uncharacterized protein Dmel_CG30269, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SV47, Q9W217
      Conserved Domains (2) summary
      pfam10601
      Location:74 → 142
      zf-LITAF-like; LITAF-like zinc ribbon domain
      pfam15165
      Location:34 → 111
      REC114-like; Meiotic recombination protein REC114-like

    2. NM_137860.4 → NP_611704.2  uncharacterized protein Dmel_CG30269, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611704.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SV47, Q9W217
      Related
      FBpp0071778
      Conserved Domains (2) summary
      pfam10601
      Location:74 → 142
      zf-LITAF-like; LITAF-like zinc ribbon domain
      pfam15165
      Location:34 → 111
      REC114-like; Meiotic recombination protein REC114-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W217 Q9W217

    Gene LinkOut

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