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    NC2alpha Negative Cofactor 2alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37471, updated on 22-Aug-2024

    Summary

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    Official Symbol
    NC2alphaprovided by FlyBase
    Official Full Name
    Negative Cofactor 2alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034650
    Locus tag
    Dmel_CG10318
    See related
    AllianceGenome:FB:FBgn0034650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10318; dDrap; dDrap1; dDrap1/dNC2a; Dmel\CG10318; dNC2; Dr1-Drap1; Drap1; NC2; Nc2alpha
    Summary
    Enables core promoter sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in organism and pole plasm. Orthologous to human DRAP1 (DR1 associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    57F7-57F7; 2-96 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21670152..21671593)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17557657..17559098)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class M Neighboring gene uncharacterized protein Neighboring gene stumble

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oxymoron no more: the expanding world of heterochromatic genes. Yasuhara JC, et al. Trends Genet, 2006 Jun. PMID 16690158
    2. A basal transcription factor that activates or represses transcription. Willy PJ, et al. Science, 2000 Nov 3. PMID 11062130
    3. The RNA Polymerase II Core Promoter in Drosophila. Vo Ngoc L, et al. Genetics, 2019 May. PMID 31053615, Free PMC Article
    4. TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription. Hsu JY, et al. Genes Dev, 2008 Sep 1. PMID 18703680, Free PMC Article
    5. Maternal RNAs encoding transcription factors for germline-specific gene expression in Drosophila embryos. Yatsu J, et al. Int J Dev Biol, 2008. PMID 18956321

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables core promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of negative cofactor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    negative cofactor 2alpha
    Names
    CG10318-PA
    NC2alpha-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21670152..21671593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137757.3 → NP_611601.2  negative cofactor 2alpha [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611601.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GSP1, Q9W2E3
      Related
      FBpp0071583
      Conserved Domains (1) summary
      pfam00808
      Location:11 → 74
      CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MLV5 Q8MLV5
    Q9GSP1 Q9GSP1
    Q9W2E3 Q9W2E3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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