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    CG10527 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37393, updated on 27-Aug-2024

    Summary

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    Official Symbol
    CG10527provided by FlyBase
    Primary source
    FLYBASE:FBgn0034583
    Locus tag
    Dmel_CG10527
    See related
    AllianceGenome:FB:FBgn0034583
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10527; FAMeT
    Summary
    Located in cytoplasm. Is expressed in several structures, including adult head; glial cell; hindgut; reproductive system; and ring gland. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    57B16-57B16; 2-92 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21070368..21072789, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16957873..16960294, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44703 Neighboring gene Chitinase 4 Neighboring gene antisense RNA:CR44704 Neighboring gene Chitinase 9 Neighboring gene Trehalase Neighboring gene Rabaptin-5 Neighboring gene uncharacterized protein Neighboring gene Gar1 ribonucleoprotein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila CG10527 mutants are resistant to juvenile hormone and its analog methoprene. Zhang H, et al. Biochem Biophys Res Commun, 2010 Oct 15. PMID 20833126
    2. A putative farnesoic acid O-methyltransferase (FAMeT) orthologue in Drosophila melanogaster (CG10527): relationship to juvenile hormone biosynthesis? Burtenshaw SM, et al. Peptides, 2008 Feb. PMID 18242777
    3. Methyl farnesoate plays a dual role in regulating Drosophila metamorphosis. Wen D, et al. PLoS Genet, 2015 Mar. PMID 25774983, Free PMC Article
    4. The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis. Zhang YQ, et al. Dev Biol, 2004 Jun 15. PMID 15183715
    5. Minor proteins and enzymes of the Drosophila eggshell matrix. Fakhouri M, et al. Dev Biol, 2006 May 1. PMID 16515779, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CG10527 plays little, if any, role in juvenile hormone (JH) biosynthesis but may participate in the JH signaling pathway.
      Title: Drosophila CG10527 mutants are resistant to juvenile hormone and its analog methoprene.
    2. Data suggest that FAMeT does not have the appropiate protein domains to serve directly as a FAMeT and cannot enzymatically convert farnesoic cid to methyl farnesoate.
      Title: A putative farnesoic acid O-methyltransferase (FAMeT) orthologue in Drosophila melanogaster (CG10527): relationship to juvenile hormone biosynthesis?
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables farnesoic acid O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10527-PA
    farnesoic acid O-methyltransferase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21070368..21072789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137700.4 → NP_611544.1  uncharacterized protein Dmel_CG10527 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611544.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MR08, Q9W2M4
      Related
      FBpp0071470
      Conserved Domains (3) summary
      smart00696
      Location:226 → 296
      DM9; Repeats found in Drosophila proteins
      pfam11901
      Location:180 → 286
      DUF3421; Protein of unknown function (DUF3421)
      pfam12248
      Location:35 → 133
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MR08 Q8MR08
    Q9W2M4 Q9W2M4

    Gene LinkOut

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