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    CAH15 Carbonic anhydrase 15 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37366, updated on 22-Aug-2024

    Summary

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    Official Symbol
    CAH15provided by FlyBase
    Official Full Name
    Carbonic anhydrase 15provided by FlyBase
    Primary source
    FLYBASE:FBgn0034560
    Locus tag
    Dmel_CG9235
    See related
    AllianceGenome:FB:FBgn0034560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9235; Dmel\CG9235
    Summary
    Predicted to enable hydro-lyase activity. Predicted to be involved in one-carbon metabolic process. Human ortholog(s) of this gene implicated in cerebellar ataxia, mental retardation and dysequlibrium syndrome. Orthologous to human CA8 (carbonic anhydrase 8). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    57B4-57B4; 2-92 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20909704..20910801)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16797209..16798306)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Calcium and integrin binding family member 2 Neighboring gene orthopedia Neighboring gene antisense RNA:CR43160 Neighboring gene Retinal Homeobox Neighboring gene ncRNA Neighboring gene Actin 57B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Carbonic anhydrases and anion transport in mosquito midgut pH regulation. Linser PJ, et al. J Exp Biol, 2009 Jun. PMID 19448076, Free PMC Article
    2. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article
    3. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208
    4. High-fidelity promoter profiling reveals widespread alternative promoter usage and transposon-driven developmental gene expression. Batut P, et al. Genome Res, 2013 Jan. PMID 22936248, Free PMC Article
    5. Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species. Sanfilippo P, et al. Genome Biol, 2017 Nov 30. PMID 29191225, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in one-carbon metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase 15
    Names
    CAH15-PA
    CG9235-PA
    NP_611525.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20909704..20910801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137681.3 → NP_611525.1  carbonic anhydrase 15 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611525.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MTV2, Q9W2Q2
      Related
      FBpp0071446
      Conserved Domains (1) summary
      cd03122
      Location:82 → 325
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MTV2 Q8MTV2
    Q9W2Q2 Q9W2Q2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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