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    PCNA Proliferating cell nuclear antigen [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37290, updated on 4-Jul-2024

    Summary

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    Official Symbol
    PCNAprovided by FlyBase
    Official Full Name
    Proliferating cell nuclear antigenprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005655
    Locus tag
    Dmel_CG9193
    See related
    AllianceGenome:FB:FBgn0005655
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    53/13; CG9193; Dmel\CG9193; DmPCNA; DmPCNA1; dPCNA; l(2)02448; l(2)56F; l(2)56Fa; l(2)s1534; mus 209; mus209; Mus209; MUS209; pcna; Pcna; PCNA/mus209; PCNA1
    Summary
    Enables chromatin binding activity. Involved in several processes, including mitotic spindle organization; response to hydrogen peroxide; and response to methyl methanesulfonate. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including embryonic brain; extended germ band embryo; gonad; gut; and pronucleus. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human PCNA (proliferating cell nuclear antigen). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See PCNA in Genome Data Viewer
    Location:
    56F11-56F11; 2-90 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20261754..20262883, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16149259..16150388, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Arginyltransferase 1 Neighboring gene Hormone-sensitive lipase Neighboring gene plutonium Neighboring gene Ribosomal protein S18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Superresolution imaging of chromatin fibers to visualize epigenetic information on replicative DNA. Wooten M, et al. Nat Protoc, 2020 Mar. PMID 32051613, Free PMC Article
    2. Illuminating DNA replication during Drosophila development using TALE-lights. Yuan K, et al. Curr Biol, 2014 Feb 17. PMID 24556431, Free PMC Article
    3. Structure of PCNA from Drosophila melanogaster. Wang K, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Apr 1. PMID 23545643, Free PMC Article
    4. Germline genomic instability in PCNA mutants of Drosophila: DNA fingerprinting and microsatellite analysis. López A, et al. Mutat Res, 2005 Mar 1. PMID 15708584
    5. Site-specific mutagenesis of Drosophila proliferating cell nuclear antigen enhances its effects on calf thymus DNA polymerase delta. Mozzherin DJ, et al. BMC Biochem, 2004 Aug 13. PMID 15310391, Free PMC Article

    See all (330) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that regulation of e2f1 and PCNA by DREF in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.
      Title: Control of e2f1 and PCNA by Drosophila transcription factor DREF.
    2. crystal of DmPCNA diffracted to 2.0 A resolution and belonged to space group H3, with unit-cell parameters a = b = 151.16, c = 38.28 A
      Title: Structure of PCNA from Drosophila melanogaster.
    3. We observed that SUUR chromosomal localization changed along with PCNA pattern and these proteins largely co-localized during the late S-phase in salivary glands.
      Title: Drosophila SUUR protein associates with PCNA and binds chromatin in a cell cycle-dependent manner.
    4. E2F regulation of PCNA is dispensable for viability, but is nonetheless important for normal Drosophila development.
      Title: The contribution of E2F-regulated transcription to Drosophila PCNA gene function.
    5. A Q123V mutation dramaticly enhances the abilities of Drosophila PCNA to stimulate calf thymus pol delta. Replacing the entire interdomain connector loop AA 119-133 with the corresponding residues from human PCNA results in additional enhancement.
      Title: Site-specific mutagenesis of Drosophila proliferating cell nuclear antigen enhances its effects on calf thymus DNA polymerase delta.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA polymerase processivity factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA polymerase processivity factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in eggshell chorion gene amplification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in leading strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mismatch repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to UV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to methyl methanesulfonate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PCNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear replication fork IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proliferating cell nuclear antigen
    Names
    CG9193-PA
    CG9193-PB
    PCNA-PA
    PCNA-PB
    Proliferating-cell-nuclear-antigen
    mutagen-sensitive 209
    proliferating-cell nuclear antigen

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20261754..20262883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057557.4 → NP_476905.1  proliferating cell nuclear antigen, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476905.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P17917, Q540V1, Q9V909
      Related
      FBpp0085619
      Conserved Domains (1) summary
      TIGR00590
      Location:1 → 259
      pcna; proliferating cell nuclear antigen (pcna)

    2. NM_206182.2 → NP_995904.1  proliferating cell nuclear antigen, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995904.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P17917, Q540V1, Q9V909
      Conserved Domains (1) summary
      TIGR00590
      Location:1 → 259
      pcna; proliferating cell nuclear antigen (pcna)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17917.2 P17917
    Q868I9 Q868I9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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