CG15111 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG15111provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0034419
Locus tag: Dmel_CG15111
See related: AllianceGenome:FB:FBgn0034419
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Dmel\CG15111
Summary: Predicted to enable lysophospholipase activity and monoacylglycerol lipase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in PHARC syndrome. Orthologous to human ABHD12 (abhydrolase domain containing 12, lysophospholipase) and ABHD12B (abhydrolase domain containing 12B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 56B5-56B5; 2-88 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (19137372..19141034)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (15024877..15028539)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables lysophospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in monoacylglycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylserine catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uncharacterized protein

Names: CG15111-PA; CG15111-PB

NP_611397.1

EC 3.1.1.23

EC 3.1.1.5

NP_725856.1

EC 3.1.1.23

EC 3.1.1.5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

19137372..19141034

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166328.3 → NP_725856.1 uncharacterized protein Dmel_CG15111, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725856.1

Status: REVIEWED

UniProtKB/TrEMBL

A1ZBH3, Q8IGV0

Related

FBpp0085764

Conserved Domains (1) summary

pfam12695
Location:183 → 381

Abhydrolase_5; Alpha/beta hydrolase family
NM_137553.3 → NP_611397.1 uncharacterized protein Dmel_CG15111, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611397.1

Status: REVIEWED

UniProtKB/TrEMBL

A1ZBH2, Q8IGV0

Related

FBpp0085765

Conserved Domains (1) summary

pfam12695
Location:165 → 363

Abhydrolase_5; Alpha/beta hydrolase family