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    GstE5 Glutathione S transferase E5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37110, updated on 22-Aug-2024

    Summary

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    Official Symbol
    GstE5provided by FlyBase
    Official Full Name
    Glutathione S transferase E5provided by FlyBase
    Primary source
    FLYBASE:FBgn0063495
    Locus tag
    Dmel_CG17527
    See related
    AllianceGenome:FB:FBgn0063495
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17527; Dmel\CG17527; DmGSTE5; gste5; gstE5; GSTE5
    Summary
    Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See GstE5 in Genome Data Viewer
    Location:
    55C7-55C7; 2-85 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18404605..18405338)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14292110..14292843)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Glutathione S transferase E4 Neighboring gene Glutathione S transferase E6 Neighboring gene Glutathione S transferase E7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Behavioral and Transcriptional Response to Selection for Olfactory Behavior in Drosophila. Brown EB, et al. G3 (Bethesda), 2020 Apr 9. PMID 32024668, Free PMC Article
    2. Antimicrobial peptides increase tolerance to oxidant stress in Drosophila melanogaster. Zhao HW, et al. J Biol Chem, 2011 Feb 25. PMID 21148307, Free PMC Article
    3. Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness. Aw WC, et al. PLoS Genet, 2018 Nov. PMID 30399141, Free PMC Article
    4. Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site. Wongsantichon J, et al. Biosci Rep, 2015 Oct 20. PMID 26487708, Free PMC Article
    5. The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans. Kislukhin G, et al. G3 (Bethesda), 2013 Aug 7. PMID 23733889, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase E5
    Names
    CG17527-PA
    GstE5-PA
    NP_611327.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18404605..18405338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137483.3 → NP_611327.1  glutathione S transferase E5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611327.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZB70, Q5BI69
      Related
      FBpp0085854
      Conserved Domains (3) summary
      cd03177
      Location:91 → 209
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:4 → 196
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cl00388
      Location:4 → 77
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZB70 A1ZB70
    Q5BI69 Q5BI69

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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