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    Pcl Polycomblike [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37069, updated on 10-May-2024

    Summary

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    Official Symbol
    Pclprovided by FlyBase
    Official Full Name
    Polycomblikeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003044
    Locus tag
    Dmel_CG5109
    See related
    AllianceGenome:FB:FBgn0003044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5109; Dmel\CG5109; dPcl; l(2)s1859; pcl; PCL
    Summary
    Enables DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Involved in several processes, including anterior/posterior axis specification; defense response to fungus; and regulation of transcription, DNA-templated. Located in nucleus and polytene chromosome. Is expressed in several structures, including anterior ectoderm anlage; anterior endoderm anlage; extended germ band embryo; gonad; and gut section. Orthologous to human PHF1 (PHD finger protein 1); PHF19 (PHD finger protein 19); and MTF2 (metal response element binding transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Pcl in Genome Data Viewer
    Location:
    55B8-55B8; 2-84 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18135426..18139990)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14022931..14027495)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Dorsal interacting protein 3 Neighboring gene Heat shock factor Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene poly(A) binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation. Choi J, et al. Nat Struct Mol Biol, 2017 Dec. PMID 29058710
    2. The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster. Coulson M, et al. Genomics, 1998 Mar 15. PMID 9545646
    3. Multidimensional Proteomics Identifies Declines in Protein Homeostasis and Mitochondria as Early Signals for Normal Aging and Age-associated Disease in Drosophila. Yang L, et al. Mol Cell Proteomics, 2019 Oct. PMID 31434710, Free PMC Article
    4. An aromatic cage is required but not sufficient for binding of Tudor domains of the Polycomblike protein family to H3K36me3. Gatchalian J, et al. Epigenetics, 2015. PMID 25923537, Free PMC Article
    5. Structure of an atypical Tudor domain in the Drosophila Polycomblike protein. Friberg A, et al. Protein Sci, 2010 Oct. PMID 20669242, Free PMC Article

    See all (243) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differentiating Drosophila female germ cells initiate Polycomb silencing by regulating PRC2-interacting proteins.
      Title: Differentiating Drosophila female germ cells initiate Polycomb silencing by regulating PRC2-interacting proteins.
    2. Data suggests that Pcl-Tudor may engage in intra- or intermolecular interactions through an exposed hydrophobic surface patch.
      Title: Structure of an atypical Tudor domain in the Drosophila Polycomblike protein.
    3. novel larval complex that contains the distinct polycomb protein Polycomblike ehich binds to the win imaginal discs.
      Title: Recruitment of Drosophila Polycomb-group proteins by Polycomblike, a component of a novel protein complex in larvae.
    4. A Pcl-PSC2 complex is the histone methyltransferase that generates the high levels of histone3-lysine27 trimethylation in Polycomb target genes that are needed to maintain a Polycomb-repressed chromatin state.
      Title: Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes.
    5. Consistent with these biochemical and cytological results, Rpd3 mutations enhance the phenotypes of Pcl mutants, further indicating that RPD3 is required for PcG silencing and possibly for PCL function
      Title: A 1-megadalton ESC/E(Z) complex from Drosophila that contains polycomblike and RPD3.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables methylated histone binding IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polycomblike
    Names
    CG5109-PA
    CG5109-PB
    Pcl-PA
    Pcl-PB
    Polycomb-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18135426..18139990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274138.2 → NP_001261067.1  polycomblike, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261067.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24459, Q8T8P9, Q9V8C2
      UniProtKB/TrEMBL
      A0A0B4KEZ1
      Conserved Domains (4) summary
      smart00333
      Location:350 → 399
      TUDOR; Tudor domain
      cd15503
      Location:514 → 565
      PHD2_MTF2_PHF19_like; PHD finger 2 found in polycomb repressive complex 2 (PRC2)-associated polycomb-like (PCL) family proteins MTF2, PHF19, and similar proteins
      pfam14061
      Location:985 → 1032
      Mtf2_C; Polycomb-like MTF2 factor 2
      cl22851
      Location:426 → 469
      PHD_SF; PHD finger superfamily

    2. NM_057324.6 → NP_476672.1  polycomblike, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476672.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24459, Q8T8P9, Q9V8C2
      UniProtKB/TrEMBL
      A0A0B4KEZ1
      Related
      FBpp0085914
      Conserved Domains (4) summary
      smart00333
      Location:350 → 399
      TUDOR; Tudor domain
      cd15503
      Location:514 → 565
      PHD2_MTF2_PHF19_like; PHD finger 2 found in polycomb repressive complex 2 (PRC2)-associated polycomb-like (PCL) family proteins MTF2, PHF19, and similar proteins
      pfam14061
      Location:985 → 1032
      Mtf2_C; Polycomb-like MTF2 factor 2
      cl22851
      Location:426 → 469
      PHD_SF; PHD finger superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEZ1 A0A0B4KEZ1
    Q24459.2 Q24459

    Gene LinkOut

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