Bap55 Brahma associated protein 55kD [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Bap55provided by FlyBase
Official Full Name: Brahma associated protein 55kDprovided by FlyBase
Primary source: FLYBASE:FBgn0025716
Locus tag: Dmel_CG6546
See related: AllianceGenome:FB:FBgn0025716
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Arp4; ARP4; Baf53; BAF53; BAF55; BAP47; bap55; BAP55; CG6546; Dmel\CG6546
Summary: Predicted to enable chromatin binding activity. Involved in DNA repair-dependent chromatin remodeling; dendrite guidance; and regulation of DNA-templated transcription. Part of NuA4 histone acetyltransferase complex and brahma complex. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 76. Orthologous to several human genes including ACTL6B (actin like 6B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (17429353..17430963, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (13316858..13318468, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair-dependent chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in dendrite guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	HMP more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SWI/SNF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of brahma complex	IDA Inferred from Direct Assay more info	PubMed