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    l(2)k01209 lethal (2) k01209 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36953, updated on 22-Aug-2024

    Summary

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    Official Symbol
    l(2)k01209provided by FlyBase
    Official Full Name
    lethal (2) k01209provided by FlyBase
    Primary source
    FLYBASE:FBgn0022029
    Locus tag
    Dmel_CG4798
    See related
    AllianceGenome:FB:FBgn0022029
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4798; Dmel\CG4798; l(2)K01209; l(2)k08901
    Summary
    Predicted to enable uridine kinase activity. Predicted to be involved in pyrimidine-containing compound salvage. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including anterior endoderm anlage; embryonic/larval lymph gland; extended germ band embryo; germ layer; and gut section. Orthologous to human UCKL1 (uridine-cytidine kinase 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See l(2)k01209 in Genome Data Viewer
    Location:
    54B7-54B7; 2-82 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17420407..17425679)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13307912..13313184)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Proteasome alpha5 subunit Neighboring gene connector enhancer of ksr Neighboring gene uncharacterized protein Neighboring gene Methylthioadenosine phosphorylase Neighboring gene Brahma associated protein 55kD

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dual-tagging gene trap of novel genes in Drosophila melanogaster. Lukacsovich T, et al. Genetics, 2001 Feb. PMID 11156992, Free PMC Article
    2. Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. Kadener S, et al. Genes Dev, 2007 Jul 1. PMID 17578907, Free PMC Article
    3. Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease. Huichalaf CH, et al. Hum Mol Genet, 2019 Jun 15. PMID 30753434, Free PMC Article
    4. Genomewide analysis of Drosophila GAGA factor target genes reveals context-dependent DNA binding. van Steensel B, et al. Proc Natl Acad Sci U S A, 2003 Mar 4. PMID 12601174, Free PMC Article
    5. Adaptation to Chronic Nutritional Stress Leads to Reduced Dependence on Microbiota in Drosophila melanogaster. Erkosar B, et al. mBio, 2017 Oct 24. PMID 29066546, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in pyrimidine-containing compound salvage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lethal (2) k01209
    Names
    CG4798-PA
    CG4798-PB
    CG4798-PC
    CG4798-PD
    l(2)k01209-PA
    l(2)k01209-PB
    l(2)k01209-PC
    l(2)k01209-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17420407..17425679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166224.3 → NP_725672.2  lethal (2) k01209, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725672.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQK4
      Related
      FBpp0086069
      Conserved Domains (3) summary
      COG0572
      Location:186 → 397
      Udk; Uridine kinase [Nucleotide transport and metabolism]
      cd02023
      Location:188 → 387
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:417 → 620
      UPRTase; Uracil phosphoribosyltransferase

    2. NM_166225.3 → NP_725673.2  lethal (2) k01209, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725673.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQK4
      Related
      FBpp0086070
      Conserved Domains (3) summary
      COG0572
      Location:186 → 397
      Udk; Uridine kinase [Nucleotide transport and metabolism]
      cd02023
      Location:188 → 387
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:417 → 620
      UPRTase; Uracil phosphoribosyltransferase

    3. NM_137362.4 → NP_611206.3  lethal (2) k01209, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611206.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAS3
      Conserved Domains (3) summary
      COG0572
      Location:121 → 332
      Udk; Uridine kinase [Nucleotide transport and metabolism]
      cd02023
      Location:123 → 322
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:352 → 555
      UPRTase; Uracil phosphoribosyltransferase

    4. NM_166226.3 → NP_725674.2  lethal (2) k01209, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725674.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQK4
      Related
      FBpp0086071
      Conserved Domains (3) summary
      COG0572
      Location:186 → 397
      Udk; Uridine kinase [Nucleotide transport and metabolism]
      cd02023
      Location:188 → 387
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:417 → 620
      UPRTase; Uracil phosphoribosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAS3 A1ZAS3
    Q8MQK4 Q8MQK4

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