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    GstS1 Glutathione S transferase S1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36927, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GstS1provided by FlyBase
    Official Full Name
    Glutathione S transferase S1provided by FlyBase
    Primary source
    FLYBASE:FBgn0010226
    Locus tag
    Dmel_CG8938
    See related
    AllianceGenome:FB:FBgn0010226
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8938; dHPGDS; Dmel\CG8938; DmGst-2; DmGST-2; DmGST2; DmGSTS1; DmGstS1-1; DmGSTS1-1; Est2; gst; GST; GST S1; GST-2; GST-S1; Gst2; GST2; gstD2; GSTII; GSTs; GSTS; gsts1; GSTS1; GstS1-1; l(2)04227; l(2)k08805; lincRNA.330; n(2)06253; S1
    Summary
    Enables glutathione peroxidase activity and glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including adult head; gut section; head epidermis primordium; mesoderm; and nephrocyte. Orthologous to human HPGDS (hematopoietic prostaglandin D synthase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See GstS1 in Genome Data Viewer
    Location:
    53F7-53F8; 2-81 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17093246..17099501, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12980751..12987006, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Sphingosine-1-phosphate lyase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants. Righi V, et al. Int J Mol Med, 2014 Jul. PMID 24789699
    2. Local alignment statistics. Altschul SF, et al. Methods Enzymol, 1996. PMID 8743700
    3. Crystallization and preliminary X-ray analysis of Drosophila glutathione S-transferase-2. Agianian B, et al. Acta Crystallogr D Biol Crystallogr, 2001 May. PMID 11320318
    4. Isolation of a Drosophila gene encoding glutathione S-transferase. Beall C, et al. Biochem Genet, 1992 Oct. PMID 1445191
    5. Effects of social isolation on neuromuscular excitability and aggressive behaviors in Drosophila: altered responses by Hk and gsts1, two mutations implicated in redox regulation. Ueda A, et al. J Neurogenet, 2009. PMID 19863269, Free PMC Article

    See all (138) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduced Function of the Glutathione S-Transferase S1 Suppresses Behavioral Hyperexcitability in Drosophila Expressing Mutant Voltage-Gated Sodium Channels.
      Title: Reduced Function of the Glutathione S-Transferase S1 Suppresses Behavioral Hyperexcitability in Drosophila Expressing Mutant Voltage-Gated Sodium Channels.
    2. The GST2 mutation is associated with insulin resistance and apoptosis in Drosophila.
      Title: In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants.
    3. This study found that mutations of two genes, Hyperkinetic (Hk) and glutathione S-transferase-S1 (gsts1), alter the response to social isolation in Drosophila.
      Title: Effects of social isolation on neuromuscular excitability and aggressive behaviors in Drosophila: altered responses by Hk and gsts1, two mutations implicated in redox regulation.
    4. Crystal structure of GST-2 at 1.75A resolution: structure of a Drosophila sigma class glutathione S-transferase reveals a novel active site topography suited for lipid peroxidation products
      Title: Structure of a Drosophila sigma class glutathione S-transferase reveals a novel active site topography suited for lipid peroxidation products.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables prostaglandin-D synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase S1
    Names
    CG8938-PA
    CG8938-PB
    CG8938-PC
    CG8938-PD
    Glutathione-S-Transferase 2
    GstS1-PA
    GstS1-PB
    GstS1-PC
    GstS1-PD
    glutathione S transferase 2
    glutathione S-transferase
    glutathione S-transferase 2
    glutathione S-transferase S1
    glutathione S-transferase-2
    glutathione S-transferase-S1
    glutathione transferase-related protein
    glutathione-S-transferase
    glutathione-S-transferase (GST) S1
    NP_001261040.1
    NP_523767.2
    NP_725653.1
    NP_725654.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17093246..17099501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274111.1 → NP_001261040.1  glutathione S transferase S1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261040.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFT5
      Conserved Domains (3) summary
      PTZ00057
      Location:52 → 245
      PTZ00057; glutathione s-transferase; Provisional
      cd03192
      Location:129 → 232
      GST_C_Sigma_like; C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases
      cd03039
      Location:50 → 119
      GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

    2. NM_166216.2 → NP_725653.1  glutathione S transferase S1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725653.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41043, Q0E945, Q9V7Y4
      UniProtKB/TrEMBL
      A4UZL5
      Related
      FBpp0086157
      Conserved Domains (2) summary
      cd03192
      Location:129 → 231
      GST_C_Sigma_like; C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases
      cd03039
      Location:50 → 119
      GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

    3. NM_079043.3 → NP_523767.2  glutathione S transferase S1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523767.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41043, Q0E945, Q9V7Y4
      UniProtKB/TrEMBL
      A4UZL5
      Related
      FBpp0086156
      Conserved Domains (2) summary
      cd03192
      Location:129 → 231
      GST_C_Sigma_like; C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases
      cd03039
      Location:50 → 119
      GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

    4. NM_166217.3 → NP_725654.1  glutathione S transferase S1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725654.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41043, Q0E945, Q9V7Y4
      UniProtKB/TrEMBL
      A4UZL5
      Conserved Domains (2) summary
      cd03192
      Location:129 → 231
      GST_C_Sigma_like; C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases
      cd03039
      Location:50 → 119
      GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFT5 A0A0B4KFT5
    A4UZL5 A4UZL5
    P41043.2 P41043

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