U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CG7848 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36839, updated on 22-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG7848provided by FlyBase
    Primary source
    FLYBASE:FBgn0034127
    Locus tag
    Dmel_CG7848
    See related
    AllianceGenome:FB:FBgn0034127
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7848
    Summary
    Predicted to enable malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and pyruvate metabolic process. Predicted to be active in mitochondrion. Orthologous to human ME1 (malic enzyme 1); ME2 (malic enzyme 2); and ME3 (malic enzyme 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    53C4-53C4; 2-80 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16433852..16435954, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12321357..12323459, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Semaphorin 2b Neighboring gene Malic enzyme like-1 Neighboring gene Malic enzyme like-2 Neighboring gene jetboil Neighboring gene uncharacterized protein Neighboring gene Poly(ADP-ribose) polymerase 16

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The paracentric inversion In(2Rh)PL alters the centromeric organization of chromosome 2 in Drosophila melanogaster. Chlamydas S, et al. Chromosome Res, 2009. PMID 19105035
    2. Lack of global meiotic sex chromosome inactivation, and paucity of tissue-specific gene expression on the Drosophila X chromosome. Mikhaylova LM, et al. BMC Biol, 2011 May 4. PMID 21542906, Free PMC Article
    3. The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Arya GH, et al. Chem Senses, 2015 May. PMID 25687947, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables malic enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG7848-PA
    NP_611127.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16433852..16435954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137283.3 → NP_611127.1  uncharacterized protein Dmel_CG7848 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611127.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3R0
      Related
      FBpp0086304
      Conserved Domains (3) summary
      cd05312
      Location:327 → 603
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:81 → 606
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:138 → 317
      malic; Malic enzyme, N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K3R0 Q7K3R0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous