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    CG8778 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36392, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CG8778provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033761
    Locus tag
    Dmel_CG8778
    See related
    AllianceGenome:FB:FBgn0033761
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8778
    Summary
    Predicted to enable methylglutaconyl-CoA hydratase activity. Involved in cold acclimation. Predicted to be active in mitochondrion. Is expressed in adult head; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Used to study 3-methylglutaconic aciduria type 1. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 1 and renal tubular transport disease. Orthologous to several human genes including AUH (AU RNA binding methylglutaconyl-CoA hydratase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See CG8778 in Genome Data Viewer
    Location:
    49B11-49B11; 2-67 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12651301..12652487, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8538806..8539992, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Imitation SWI Neighboring gene uncharacterized protein Neighboring gene Zinc transporter 49B Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Habituation Learning Is a Widely Affected Mechanism in Drosophila Models of Intellectual Disability and Autism Spectrum Disorders. Fenckova M, et al. Biol Psychiatry, 2019 Aug 15. PMID 31272685, Free PMC Article
    2. miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila. Pandey M, et al. Elife, 2021 Jun 8. PMID 34100717, Free PMC Article
    3. Selection, recombination and demographic history in Drosophila miranda. Bachtrog D, et al. Genetics, 2006 Dec. PMID 17028331, Free PMC Article
    4. Identifying potential dietary treatments for inherited metabolic disorders using Drosophila nutrigenomics. Martelli F, et al. Cell Rep, 2024 Mar 26. PMID 38416643, Free PMC Article
    5. Cold hardening and transcriptional change in Drosophila melanogaster. Qin W, et al. Insect Mol Biol, 2005 Dec. PMID 16313561

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylglutaconyl-CoA hydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cold acclimation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8778-PA
    Enoyl-CoA hydratase
    NP_610805.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12651301..12652487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136961.3 → NP_610805.1  uncharacterized protein Dmel_CG8778 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610805.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z934
      Related
      FBpp0086993
      Conserved Domains (1) summary
      cl23717
      Location:48 → 299
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z934 A1Z934

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