Atcay ATCAY kinesin light chain interacting caytaxin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atcayprovided by RGD
Official Full Name: ATCAY kinesin light chain interacting caytaxinprovided by RGD
Primary source: RGD:1309312
See related: EnsemblRapid:ENSRNOG00000020407 AllianceGenome:RGD:1309312
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable kinesin binding activity. Involved in mitochondrion distribution and neuron projection development. Located in several cellular components, including dendrite; neuron projection terminus; and perinuclear region of cytoplasm. Used to study dystonia. Human ortholog(s) of this gene implicated in Cayman type cerebellar ataxia and cerebellar ataxia. Orthologous to human ATCAY (ATCAY kinesin light chain interacting caytaxin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 297.7) and Muscle (RPKM 26.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (9138485..9162249)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (8487763..8511527)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (11356017..11379782)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

precise targeting of the cholinergic machinery through BNIP-H is essential for the local production of acetylcholine for morphogenesis and neurotransmission
Title: BNIP-H Recruits the Cholinergic Machinery to Neurite Terminals to Promote Acetylcholine Signaling and Neuritogenesis.
nerve growth factor may stimulate the interaction of BNIP-H with Pin1 by releasing its intramolecular inhibition
Title: Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons.
Atcay mRNA is found in all brain neuronal populations.In cerebellum, it is in the molecular, Purkinje & granular layers. It may have a vital role in the development & neurophysiology of cerebellar cortex.
Title: Caytaxin deficiency causes generalized dystonia in rats.
The data of this study indicate that caytaxin plays a critical role in the molecular response of Purkinje cells to climbing fiber input. Caytaxin may also contribute to maturational events in cerebellar cortex.
Title: Caytaxin deficiency disrupts signaling pathways in cerebellar cortex.
The above data, disease phenotypes, and mutant animals suggest that Caytaxin may be essential for synaptic function.
Title: Expression and localization of Cayman ataxia-related protein, Caytaxin, is regulated in a developmental- and spatial-dependent manner.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables kinesin binding	IEA Inferred from Electronic Annotation more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in mitochondrion distribution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glutamate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glutamate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glutamate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: caytaxin

Names: ATCAY, caytaxin; ataxia, cerebellar, Cayman type

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040190.1 → NP_001035280.1 caytaxin

See identical proteins and their annotated locations for NP_001035280.1

Status: PROVISIONAL

Source sequence(s)

AY611623

UniProtKB/Swiss-Prot

Q1M168

UniProtKB/TrEMBL

A0A8I6APV9

Related

ENSRNOP00000045560.6, ENSRNOT00000041325.7

Conserved Domains (2) summary

pfam12496
Location:59 → 187

BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

pfam13716
Location:189 → 315

CRAL_TRIO_2; Divergent CRAL/TRIO domain