U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CG12384 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36224, updated on 10-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG12384provided by FlyBase
    Primary source
    FLYBASE:FBgn0033624
    Locus tag
    Dmel_CG12384
    See related
    AllianceGenome:FB:FBgn0033624
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH16986; BcDNA:RH17411; Dmel\CG12384
    Summary
    Predicted to enable death domain binding activity. Predicted to be involved in several processes, including apoptotic signaling pathway; cellular response to amino acid starvation; and negative regulation of autophagy. Is expressed in several structures, including embryonic epidermis; embryonic/larval salivary gland; and presumptive embryonic/larval digestive system. Orthologous to several human genes including DAP (death associated protein). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG12384 in Genome Data Viewer
    Location:
    47F5-47F5; 2-64 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11357902..11359176, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7245407..7246681, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene iotaTrypsin Neighboring gene transfer RNA:Selenocysteine-TCA 1-1 Neighboring gene intersex Neighboring gene separation anxiety

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. intersex, a gene required for female sexual development in Drosophila, is expressed in both sexes and functions together with doublesex to regulate terminal differentiation. Garrett-Engele CM, et al. Development, 2002 Oct. PMID 12361959
    2. A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation. Tsuboyama K, et al. PLoS Biol, 2020 Mar. PMID 32163402, Free PMC Article
    3. Base Editing of Somatic Cells Using CRISPR-Cas9 in Drosophila. Marr E, et al. CRISPR J, 2021 Dec. PMID 34813372, Free PMC Article
    4. Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq. Aspden JL, et al. Elife, 2014 Aug 21. PMID 25144939, Free PMC Article
    5. FlyAtlas 2 in 2022: enhancements to the Drosophila melanogaster expression atlas. Krause SA, et al. Nucleic Acids Res, 2022 Jan 7. PMID 34718735, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables death domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables death domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG12384-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11357902..11359176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136832.4 → NP_610676.2  uncharacterized protein Dmel_CG12384 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610676.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JRC0
      Related
      FBpp0087252
      Conserved Domains (1) summary
      pfam15228
      Location:10 → 96
      DAP; Death-associated protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JRC0 Q7JRC0
    Q8T0N9 Q8T0N9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools