PGRP-SC1a Peptidoglycan recognition protein SC1a [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PGRP-SC1aprovided by FlyBase
Official Full Name: Peptidoglycan recognition protein SC1aprovided by FlyBase
Primary source: FLYBASE:FBgn0043576
Locus tag: Dmel_CG14746
See related: AllianceGenome:FB:FBgn0043576
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14746; Dmel\CG14746; PGRP SC; pgrp-sc; PGRP-SC; pgrp-sc1; PGRP-SC1; PGRP-SC1A; picky
Summary: Predicted to enable N-acetylmuramoyl-L-alanine amidase activity. Involved in several processes, including Toll receptor ligand protein activation cascade; defense response to Gram-positive bacterium; and negative regulation of defense response to bacterium. Is expressed in embryonic/larval gut and embryonic/larval proventriculus. Orthologous to human PGLYRP1 (peptidoglycan recognition protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8709733..8710320)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4597238..4597825)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

PGRP-SC1a catalytic activity is essential for recognition and clearance of live Staphylococcus aureus.
Title: The peptidoglycan recognition protein PGRP-SC1a is essential for Toll signaling and phagocytosis of Staphylococcus aureus in Drosophila.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables N-acetylmuramoyl-L-alanine amidase activity	IEA Inferred from Electronic Annotation more info
enables N-acetylmuramoyl-L-alanine amidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables peptidoglycan binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Toll receptor ligand protein activation cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of peptidoglycan recognition protein signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidoglycan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in peptidoglycan catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in peptidoglycan catabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed

Names: CG14746-PA; PGRP-SC1a-PA; Peptidoglycan-recognition protein-SC1a precursor

NP_610407.1

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain