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    Dhc36C Dynein heavy chain at 36C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35061, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dhc36Cprovided by FlyBase
    Official Full Name
    Dynein heavy chain at 36Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013810
    Locus tag
    Dmel_CG5526
    See related
    AllianceGenome:FB:FBgn0013810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5526; dhc; Dhc; DHC; Dhc 36C; Dhc36c; DHC7A; Dmel\CG5526
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in flagellated sperm motility and sensory perception of sound. Is active in sperm flagellum. Is expressed in adult head; chordotonal neurons; spermatogonium; spermatozoon; and testis. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human DNAH7 (dynein axonemal heavy chain 7). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

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    See Dhc36C in Genome Data Viewer
    Location:
    36C10-36C10; 2-53 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17501401..17525515)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17501401..17525515)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial translation elongation factor Ts Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A family of dynein genes in Drosophila melanogaster. Rasmusson K, et al. Mol Biol Cell, 1994 Jan. PMID 8186464, Free PMC Article
    2. The Y chromosomal fertility factor Threads in Drosophila hydei harbors a functional gene encoding an axonemal dynein beta heavy chain protein. Kurek R, et al. Genetics, 1998 Jul. PMID 9649526, Free PMC Article
    3. A force balance model of early spindle pole separation in Drosophila embryos. Cytrynbaum EN, et al. Biophys J, 2003 Feb. PMID 12547760, Free PMC Article
    4. reduced ocelli encodes the leucine rich repeat protein Pray For Elves in Drosophila melanogaster. Caldwell JC, et al. Fly (Austin), 2007 May-Jun. PMID 18820435, Free PMC Article
    5. In vivo dynamics of the rough deal checkpoint protein during Drosophila mitosis. Basto R, et al. Curr Biol, 2004 Jan 6. PMID 14711415

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 17520662-17520736 mobile_element_type = transposon:INE-1{}3446

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of inner dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein heavy chain at 36C
    Names
    CG5526-PB
    CG5526-PC
    Dhc36C-PB
    Dhc36C-PC
    dynein-related heavy chain polypeptide

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17501401..17525515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382179.1 → NP_001369131.1  dynein heavy chain at 36C, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EJG3
      Conserved Domains (6) summary
      COG5245
      Location:984 → 3651
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08393
      Location:746 → 1151
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1281 → 1607
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2299 → 2561
      AAA_8; P-loop containing dynein motor region D4
      pfam12781
      Location:2950 → 3165
      AAA_9; ATP-binding dynein motor region D5
      pfam18199
      Location:3779 → 4061
      Dynein_C; Dynein heavy chain C-terminal domain

    2. NM_078867.4 → NP_523591.2  dynein heavy chain at 36C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523591.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJC6
      Conserved Domains (5) summary
      pfam03028
      Location:3304 → 4012
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:750 → 1152
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2579 → 2921
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:2950 → 3164
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1281 → 1507
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6H2EJG3 A0A6H2EJG3
    Q5BHW1 Q5BHW1
    Q9VJC6 Q9VJC6
    V9GZG7 V9GZG7

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