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    Lrr47 Leucine-rich repeat 47 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34449, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lrr47provided by FlyBase
    Official Full Name
    Leucine-rich repeat 47provided by FlyBase
    Primary source
    FLYBASE:FBgn0010398
    Locus tag
    Dmel_CG6098
    See related
    AllianceGenome:FB:FBgn0010398
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6098; CT19173; Dmel\CG6098; Lrr-47; LRR47
    Summary
    Predicted to be involved in Ras protein signal transduction. Located in cytoplasm and nucleus. Is expressed in organism. Orthologous to human LRR1 (leucine rich repeat protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Lrr47 in Genome Data Viewer
    Location:
    31F5-31F5; 2-43 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10517335..10519269)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10517335..10519269)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fatty acid transport protein 1 Neighboring gene Lipase 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence and expression of LRR47, a novel embryonic leucine rich repeat protein of Drosophila. Ntwasa M, et al. Biochim Biophys Acta, 1994 Jun 21. PMID 8018718
    2. The Goddard and Saturn Genes Are Essential for Drosophila Male Fertility and May Have Arisen De Novo. Gubala AM, et al. Mol Biol Evol, 2017 May 1. PMID 28104747, Free PMC Article
    3. Promoter sequence and expression of the leucine-rich repeat gene LRR47: evidence for cytoplasmic and nuclear localization in Drosophila embryos and cells. Buchanan SG, et al. Gene, 1998 May 12. PMID 9602138
    4. Translational control via protein-regulated upstream open reading frames. Medenbach J, et al. Cell, 2011 Jun 10. PMID 21663794
    5. New slbo-Gal4 driver lines for the analysis of border cell migration during Drosophila oogenesis. Ogienko AA, et al. Chromosoma, 2018 Dec. PMID 30030602

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Leucine-rich repeat 47
    Names
    CG6098-PA
    CG6098-PB
    Lrr47-PA
    Lrr47-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10517335..10519269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273426.1 → NP_001260355.1  Leucine-rich repeat 47, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260355.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24386, Q9VKU0
      Conserved Domains (3) summary
      sd00033
      Location:156 → 178
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:156 → 194
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:154 → 211
      LRR_8; Leucine rich repeat

    2. NM_078815.3 → NP_523539.2  Leucine-rich repeat 47, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523539.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24386, Q9VKU0
      Related
      FBpp0079681
      Conserved Domains (3) summary
      sd00033
      Location:156 → 178
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:156 → 194
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:154 → 211
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24386 Q24386
    Q9VKU0 Q9VKU0

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