ihog interference hedgehog [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ihogprovided by FlyBase
Official Full Name: interference hedgehogprovided by FlyBase
Primary source: FLYBASE:FBgn0031872
Locus tag: Dmel_CG9211
See related: AllianceGenome:FB:FBgn0031872
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9211; CT26314; Dmel\CG9211; iHog; Ihog; IHOG
Summary: Enables several functions, including coreceptor activity; hedgehog family protein binding activity; and heparin binding activity. Involved in several processes, including maintenance of protein location in extracellular region; regionalization; and smoothened signaling pathway. Located in cell surface; cytoneme; and plasma membrane. Is expressed in several structures, including dorsal epidermis primordium; embryonic anal pad; embryonic dorsal epidermis; embryonic epipharynx; and imaginal disc. Human ortholog(s) of this gene implicated in holoprosencephaly 11. Orthologous to human BOC (BOC cell adhesion associated, oncogene regulated) and CDON (cell adhesion associated, oncogene regulated). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 27C6-27C6; 2-23 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6945464..6948808, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6945464..6948808, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ihog proteins contribute to integrin-mediated focal adhesions.
Title: Ihog proteins contribute to integrin-mediated focal adhesions.
Glypicans define unique roles for the Hedgehog co-receptors boi and ihog in cytoneme-mediated gradient formation.
Title: Glypicans define unique roles for the Hedgehog co-receptors boi and ihog in cytoneme-mediated gradient formation.
These results, thus, not only reveal a mechanism for Ihog-mediated cell-cell interactions but also suggest a direct Hh-mediated regulation of both intracellular signaling and cell adhesion through Ihog.
Title: The Drosophila Hedgehog receptor component Interference hedgehog (Ihog) mediates cell-cell interactions through trans-homophilic binding.
Patched and Ihog activity are mutually required for receptor endocytosis and degradation, triggered by Hedgehog protein binding, and causing reduced levels of Ihog/Boi proteins in a stripe of cells at the anterior/posterior compartment boundary of the wing imaginal disc.
Title: Hedgehog mediated degradation of Ihog adhesion proteins modulates cell segregation in Drosophila wing imaginal discs.
Hh and its co-receptor Ihog are in exovesicles transported via cytonemes. Hh transport via exosomes along cytonemes is a significant mechanism for the restricted distribution of a lipid-modified morphogen.
Title: Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion.
Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand
Title: Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand.
analysis of balancing between hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif
Title: Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif.
A functional interaction between Ihog and members of the Shf/WIF1 family demonstrates that Ihog can increase the Wnt-inhibitory activity of vertebrate WIF1.
Title: The Drosophila WIF1 homolog Shifted maintains glypican-independent Hedgehog signaling and interacts with the Hedgehog co-receptors Ihog and Boi.
Data show that Dispatched could be involved in the regulation of vesicular trafficking necessary for basolateral release of Hh, Dlp, and Ihog.
Title: Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium.
Ihog and Boi are essential for Hedgehog signaling in Drosophila.
Title: Ihog and Boi are essential for Hedgehog signaling in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables coreceptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables hedgehog family protein binding	IDA Inferred from Direct Assay more info	PubMed
enables hedgehog family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables patched binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cuticle pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cuticle pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homotypic cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in maintenance of protein location in extracellular region	IGI Inferred from Genetic Interaction more info	PubMed
involved_in segment specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc anterior/posterior pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wing disc pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wing disc pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoneme	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interference hedgehog

Names: CG9211-PA; ihog-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

6945464..6948808 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_135241.2 → NP_609085.1 interference hedgehog [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609085.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C0PTX1, Q2XY56, Q9VM64

Related

FBpp0078993

Conserved Domains (6) summary

smart00408
Location:365 → 427

IGc2; Immunoglobulin C-2 Type

smart00410
Location:364 → 437

IG_like; Immunoglobulin like

cd00063
Location:467 → 565

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:580 → 655

fn3; Fibronectin type III domain

pfam00047
Location:265 → 330

ig; Immunoglobulin domain

cl11960
Location:314 → 377

Ig; Immunoglobulin domain