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    CG9175 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33862, updated on 10-May-2024

    Summary

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    Official Symbol
    CG9175provided by FlyBase
    Primary source
    FLYBASE:FBgn0031779
    Locus tag
    Dmel_CG9175
    See related
    AllianceGenome:FB:FBgn0031779
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG9175; Sec12
    Summary
    Predicted to enable GTPase activator activity. Involved in cell morphogenesis and protein secretion. Located in endoplasmic reticulum. Is expressed in several structures, including adult head; gut section; hindgut proper primordium; larval ventral nerve cord; and proventriculus primordium. Orthologous to human PREB (prolactin regulatory element binding). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG9175 in Genome Data Viewer
    Location:
    26B5-26B5; 2-18 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6096698..6098966, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6096698..6098966, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44773 Neighboring gene Kruppel homolog 1 Neighboring gene uncharacterized protein Neighboring gene stathmin Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 2/3 complex, subunit 4 Neighboring gene WD repeat domain 79

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of two pathways mediating protein targeting from ER to lipid droplets. Song J, et al. Nat Cell Biol, 2022 Sep. PMID 36050470, Free PMC Article
    2. The ArfGAP Drongo Promotes Actomyosin Contractility during Collective Cell Migration by Releasing Myosin Phosphatase from the Trailing Edge. Zeledon C, et al. Cell Rep, 2019 Sep 17. PMID 31533044
    3. A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. D'Ambrosio MV, et al. J Cell Biol, 2010 Nov 1. PMID 21041442, Free PMC Article
    4. Systematic analysis of the transcriptional switch inducing migration of border cells. Borghese L, et al. Dev Cell, 2006 Apr. PMID 16580994, Free PMC Article
    5. Genome-wide analyses of Shavenbaby target genes reveals distinct features of enhancer organization. Menoret D, et al. Genome Biol, 2013 Aug 23. PMID 23972280, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of COPII vesicle coating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9175-PA
    CG9175-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6096698..6098966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164681.3 → NP_723155.1  uncharacterized protein Dmel_CG9175, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723155.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SQ7, Q9VMH4
      Related
      FBpp0078843
      Conserved Domains (3) summary
      COG2319
      Location:190 → 421
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:190 → 226
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:190 → 420
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_135151.4 → NP_608995.2  uncharacterized protein Dmel_CG9175, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608995.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SQ7, Q9VMH4
      Related
      FBpp0078842
      Conserved Domains (3) summary
      COG2319
      Location:190 → 421
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:190 → 226
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:190 → 420
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SQ7 Q95SQ7
    Q9VMH4 Q9VMH4

    Gene LinkOut

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