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    Fbw5 F-box and WD repeat domain containing 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33854, updated on 22-Aug-2024

    Summary

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    Official Symbol
    Fbw5provided by FlyBase
    Official Full Name
    F-box and WD repeat domain containing 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0031773
    Locus tag
    Dmel_CG9144
    See related
    AllianceGenome:FB:FBgn0031773
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9144; dFbw5; Dmel\CG9144; FBgn 31773; FBXW2
    Summary
    Involved in positive regulation of protein catabolic process and protein ubiquitination. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex and SCF ubiquitin ligase complex. Orthologous to human FBXW5 (F-box and WD repeat domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    26B4-26B4; 2-18 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6063562..6065953, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6063562..6065953, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 51 kDa subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime. Ko HW, et al. Nature, 2002 Dec 12. PMID 12442174
    2. WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Hu J, et al. Genes Dev, 2008 Apr 1. PMID 18381890, Free PMC Article
    3. FipoQ/FBXO33, a Cullin-1-based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein. Chen ZS, et al. J Neurochem, 2019 Jun. PMID 30685895
    4. SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56. Barbosa P, et al. J Cell Biol, 2021 Feb 1. PMID 33382409, Free PMC Article
    5. A conserved F-box gene with unusual transcript localization. Das T, et al. Dev Genes Evol, 2002 Apr. PMID 11976951

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
    Inferred from Sequence Model
    more info
    		  
    involved_in positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SCF ubiquitin ligase complex ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    F-box and WD repeat domain containing 5
    Names
    CG9144-PA
    Fbw5-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6063562..6065953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135145.2 → NP_608989.1  F-box and WD repeat domain containing 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608989.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMI1
      Related
      FBpp0078846
      Conserved Domains (5) summary
      smart00320
      Location:126 → 157
      WD40; WD40 repeats
      COG2319
      Location:538 → 644
      WD40; WD40 repeat [General function prediction only]
      pfam12937
      Location:36 → 82
      F-box-like; F-box-like
      sd00039
      Location:566 → 600
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:553 → 637
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMI1 Q9VMI1

    Gene LinkOut

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