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    DIP-theta Dpr-interacting protein theta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33795, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DIP-thetaprovided by FlyBase
    Official Full Name
    Dpr-interacting protein thetaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051646
    Locus tag
    Dmel_CG31646
    See related
    AllianceGenome:FB:FBgn0051646
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    31646; CG14008; CG14009; CG31646; CT33566; DIPtheta; Dmel\CG31646
    Summary
    Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in optic lobe intrinsic neurons. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); LSAMP (limbic system associated membrane protein); and NTM (neurotrimin). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

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    See DIP-theta in Genome Data Viewer
    Location:
    25F1-25F2; 2-17 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5626291..5658560, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5626291..5658560, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44796 Neighboring gene Cytochrome P450 6a16 Neighboring gene long non-coding RNA:CR44822 Neighboring gene mir-959 stem loop Neighboring gene mir-960 stem loop Neighboring gene mir-961 stem loop Neighboring gene mir-962 stem loop Neighboring gene mir-963 stem loop Neighboring gene mir-964 stem loop Neighboring gene long non-coding RNA:CR44821 Neighboring gene Heat shock protein 60C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila septin interacting protein 1 regulates neurogenesis in the early developing larval brain. Wei JY, et al. Sci Rep, 2022 Jan 7. PMID 34997175, Free PMC Article
    2. An in vivo screen for neuronal genes involved in obesity identifies Diacylglycerol kinase as a regulator of insulin secretion. Trinh I, et al. Mol Metab, 2019 Jan. PMID 30389349, Free PMC Article
    3. The oscillating miRNA 959-964 cluster impacts Drosophila feeding time and other circadian outputs. Vodala S, et al. Cell Metab, 2012 Nov 7. PMID 23122660, Free PMC Article
    4. Classifying Protein-Protein Binding Affinity with Free-Energy Calculations and Machine Learning Approaches. Goulard Coderc de Lacam E, et al. J Chem Inf Model, 2024 Feb 12. PMID 38272021
    5. Testing candidate genes for attention-deficit/hyperactivity disorder in fruit flies using a high throughput assay for complex behavior. Rohde PD, et al. Fly (Austin), 2016 Jan 2. PMID 26954609, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in synapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dpr-interacting protein theta
    Names
    CG31646-PA
    DIP-theta-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5626291..5658560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164653.3 → NP_723103.1  Dpr-interacting protein theta [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723103.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5E0, Q9VMN6
      Related
      FBpp0078746
      Conserved Domains (3) summary
      smart00408
      Location:247 → 310
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:240 → 324
      IG_like; Immunoglobulin like
      cl11960
      Location:327 → 419
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMN6 Q9VMN6

    Gene LinkOut

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