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    atp13a1 ATPase 13A1 [ Danio rerio (zebrafish) ]

    Gene ID: 334466, updated on 2-Nov-2024

    Summary

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    Official Symbol
    atp13a1provided by ZNC
    Official Full Name
    ATPase 13A1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2804
    See related
    Ensembl:ENSDARG00000029931 AllianceGenome:ZFIN:ZDB-GENE-040426-2804
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    atp13a; zgc:63781; wu:fi75c10; hm:zehn0386
    Summary
    Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity; P-type ion transporter activity; and membrane protein dislocase activity. Predicted to be involved in extraction of mislocalized protein from ER membrane; intracellular calcium ion homeostasis; and transmembrane transport. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ATP13A1 (ATPase 13A1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See atp13a1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (52899801..52952026)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (52645138..52697363)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene LIM homeobox transcription factor 1, alpha-like Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 5 Neighboring gene golgin subfamily A member 6-like protein 22 Neighboring gene DSN1 component of MIS12 kinetochore complex Neighboring gene pre-B-cell leukemia transcription factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival. Lopes da Fonseca T, et al. Brain Res Bull, 2013 Jan. PMID 23123961
    2. Glucocorticoid Treatment Leads to Aberrant Ion and Macromolecular Transport in Regenerating Zebrafish Fins. Schmidt JR, et al. Front Endocrinol (Lausanne), 2019. PMID 31636606, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type ion transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables membrane protein dislocase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in extraction of mislocalized protein from ER membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum transmembrane helix translocase
    Names
    ATPase type 13A
    ATPase type 13A1
    NP_001001403.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001403.2 → NP_001001403.2  endoplasmic reticulum transmembrane helix translocase

      Status: PROVISIONAL

      Source sequence(s)
      CT573476
      UniProtKB/TrEMBL
      A0A8M1MZL3, F1R1X4
      Related
      ENSDARP00000058957.5, ENSDART00000058958.6
      Conserved Domains (3) summary
      COG4087
      Location:804 → 861
      COG4087; Soluble P-type ATPase [General function prediction only]
      TIGR01657
      Location:84 → 1155
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:277 → 485
      E1-E2_ATPase; E1-E2 ATPase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      52899801..52952026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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