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    CG4238 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33377, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CG4238provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031384
    Locus tag
    Dmel_CG4238
    See related
    AllianceGenome:FB:FBgn0031384
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4238
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of apoptotic process and ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to human AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See CG4238 in Genome Data Viewer
    Location:
    22B8-22C1; 2-3 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2009859..2030788)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2009859..2030788)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene transfer RNA:Glutamine-CTG 2-2 Neighboring gene transfer RNA:Glutamine-CTG 2-3 Neighboring gene transfer RNA:Glutamine-CTG 2-4 Neighboring gene transfer RNA:Glutamine-CTG 3-1 Neighboring gene transfer RNA:Glutamine-CTG 2-5 Neighboring gene snoRNA:Orphan C/D box 14 Neighboring gene transfer RNA:Glycine-GCC 1-2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coordinated repression and activation of two transcriptional programs stabilizes cell fate during myogenesis. Ciglar L, et al. Development, 2014 Jul. PMID 24961800, Free PMC Article
    2. PRE-mediated bypass of two Su(Hw) insulators targets PcG proteins to a downstream promoter. Comet I, et al. Dev Cell, 2006 Jul. PMID 16824958
    3. A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. Ketosugbo KF, et al. PLoS One, 2017. PMID 29117266, Free PMC Article
    4. Using single-cell RNA sequencing to generate predictive cell-type-specific split-GAL4 reagents throughout development. Chen YD, et al. Proc Natl Acad Sci U S A, 2023 Aug 8. PMID 37523539, Free PMC Article
    5. Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. Gan Q, et al. Cell Res, 2010 Jul. PMID 20440302, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4238-PD
    CG4238-PE
    CG4238-PF
    CG4238-PG
    CG4238-PH
    CG4238-PI
    CG4238-PJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2009859..2030788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103583.3 → NP_001097053.2  uncharacterized protein Dmel_CG4238, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097053.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYT2, Q8MZA5
      Conserved Domains (6) summary
      smart00454
      Location:41 → 99
      SAM; Sterile alpha motif
      smart00119
      Location:633 → 965
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      smart00557
      Location:229 → 327
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00078
      Location:606 → 966
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:229 → 327
      Filamin; Filamin/ABP280 repeat
      cl15755
      Location:44 → 73
      SAM_superfamily; SAM (Sterile alpha motif )

    2. NM_001272966.1 → NP_001259895.1  uncharacterized protein Dmel_CG4238, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259895.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE16, Q8MZA5
      Conserved Domains (6) summary
      smart00454
      Location:41 → 99
      SAM; Sterile alpha motif
      smart00119
      Location:627 → 959
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      smart00557
      Location:229 → 327
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00078
      Location:600 → 960
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:229 → 327
      Filamin; Filamin/ABP280 repeat
      cl15755
      Location:44 → 73
      SAM_superfamily; SAM (Sterile alpha motif )

    3. NM_001272965.1 → NP_001259894.1  uncharacterized protein Dmel_CG4238, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259894.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYT3, Q8MZA5
      Conserved Domains (4) summary
      smart00119
      Location:593 → 925
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      smart00557
      Location:189 → 287
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00078
      Location:566 → 926
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:189 → 287
      Filamin; Filamin/ABP280 repeat

    4. NM_001272968.1 → NP_001259897.1  uncharacterized protein Dmel_CG4238, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259897.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYT3, Q8MZA5
      Conserved Domains (4) summary
      smart00119
      Location:593 → 925
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      smart00557
      Location:189 → 287
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00078
      Location:566 → 926
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:189 → 287
      Filamin; Filamin/ABP280 repeat

    5. NM_001103582.2 → NP_001097052.2  uncharacterized protein Dmel_CG4238, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097052.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYT3, Q8MZA5
      Conserved Domains (4) summary
      smart00119
      Location:593 → 925
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      smart00557
      Location:189 → 287
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00078
      Location:566 → 926
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:189 → 287
      Filamin; Filamin/ABP280 repeat

    6. NM_001272967.1 → NP_001259896.1  uncharacterized protein Dmel_CG4238, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259896.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ67
      Conserved Domains (4) summary
      smart00119
      Location:642 → 974
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      smart00557
      Location:238 → 336
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00078
      Location:615 → 975
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:238 → 336
      Filamin; Filamin/ABP280 repeat

    7. NM_134796.4 → NP_608640.2  uncharacterized protein Dmel_CG4238, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608640.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ67
      Conserved Domains (4) summary
      smart00119
      Location:642 → 974
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      smart00557
      Location:238 → 336
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00078
      Location:615 → 975
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:238 → 336
      Filamin; Filamin/ABP280 repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYT2 A8DYT2
    A8DYT3 A8DYT3
    M9PE16 M9PE16
    Q8MZA5 Q8MZA5
    Q9VQ67 Q9VQ67

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