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    agfg1a ArfGAP with FG repeats 1a [ Danio rerio (zebrafish) ]

    Gene ID: 327597, updated on 2-Nov-2024

    Summary

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    Official Symbol
    agfg1aprovided by ZNC
    Official Full Name
    ArfGAP with FG repeats 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5808
    See related
    Ensembl:ENSDARG00000030020 AllianceGenome:ZFIN:ZDB-GENE-030131-5808
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hrb; agfg1; wu:fb14f05; wu:fi19d11
    Summary
    Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in acrosome assembly; intermediate filament organization; and spermatid nucleus differentiation. Predicted to be active in cytoplasmic vesicle. Is expressed in intermediate cell mass of mesoderm and ventral mesoderm. Orthologous to human AGFG1 (ArfGAP with FG repeats 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See agfg1a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (35156413..35212444, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (35298445..35354877, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene palmitoyl-protein thioesterase 2a, tandem duplicate 4 Neighboring gene uncharacterized LOC103908855 Neighboring gene solute carrier family 19 member 3a Neighboring gene mitochondrial ribosomal protein L44 Neighboring gene mitochondrial fission factor a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid nucleus differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP domain and FG repeat-containing protein 1a
    Names
    ArfGAP with FG repeats 1
    HIV-1 Rev binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199835.1 → NP_956129.1  arf-GAP domain and FG repeat-containing protein 1a

      See identical proteins and their annotated locations for NP_956129.1

      Status: PROVISIONAL

      Source sequence(s)
      AY423015
      UniProtKB/TrEMBL
      Q6TEN4
      Related
      ENSDARP00000043959.6, ENSDART00000043960.8
      Conserved Domains (1) summary
      smart00105
      Location:17 → 134
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      35156413..35212444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009291790.4 → XP_009290065.1  arf-GAP domain and FG repeat-containing protein 1a isoform X5

      UniProtKB/TrEMBL
      A0A8M3AQ06
      Conserved Domains (1) summary
      smart00105
      Location:17 → 134
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

    2. XM_009291789.4 → XP_009290064.1  arf-GAP domain and FG repeat-containing protein 1a isoform X4

      UniProtKB/TrEMBL
      A0A8M3ASW7
      Conserved Domains (1) summary
      smart00105
      Location:17 → 134
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

    3. XM_068213473.1 → XP_068069574.1  arf-GAP domain and FG repeat-containing protein 1a isoform X2

    4. XM_021481344.2 → XP_021337019.1  arf-GAP domain and FG repeat-containing protein 1a isoform X3

      UniProtKB/TrEMBL
      A0A8M9QH37
      Conserved Domains (2) summary
      smart00105
      Location:17 → 134
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cl26386
      Location:365 → 578
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    5. XM_021481343.2 → XP_021337018.1  arf-GAP domain and FG repeat-containing protein 1a isoform X1

      UniProtKB/TrEMBL
      A0A8M9QBV1
      Conserved Domains (2) summary
      smart00105
      Location:17 → 134
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cl26386
      Location:365 → 594
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    Nucleotide Protein Strain
    Heading Accession and Version

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