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    Polr3I RNA polymerase III subunit I [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32678, updated on 22-Aug-2024

    Summary

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    Official Symbol
    Polr3Iprovided by FlyBase
    Official Full Name
    RNA polymerase III subunit Iprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030801
    Locus tag
    Dmel_CG4875
    See related
    AllianceGenome:FB:FBgn0030801
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4875; Dmel\CG4875; dRCP; Rcp; RPC17
    Summary
    Predicted to enable nucleotide binding activity. Involved in positive regulation of G protein-coupled receptor signaling pathway. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including embryonic brain; embryonic/larval midgut; extended germ band embryo; and larval ventral nerve cord. Orthologous to human CRCP (CGRP receptor component). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    Location:
    15B4-15B4; 1-56 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16884581..16886612)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16778614..16780645)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nitrogen permease regulator-like 2 Neighboring gene long non-coding RNA:CR43768 Neighboring gene Density regulated protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel diuretic hormone receptor in Drosophila: evidence for conservation of CGRP signaling. Johnson EC, et al. J Exp Biol, 2005 Apr. PMID 15781884
    2. In silico identification of Drosophila melanogaster genes encoding RNA polymerase subunits. Marygold SJ, et al. MicroPubl Biol, 2020 Oct 20. PMID 33274328, Free PMC Article
    3. An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity. Xu C, et al. Proc Natl Acad Sci U S A, 2020 Jan 7. PMID 31852821, Free PMC Article
    4. Identification of neural outgrowth genes using genome-wide RNAi. Sepp KJ, et al. PLoS Genet, 2008 Jul 4. PMID 18604272, Free PMC Article
    5. X-chromosome-wide profiling of MSL-1 distribution and dosage compensation in Drosophila. Legube G, et al. Genes Dev, 2006 Apr 1. PMID 16547175, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase III promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase III promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase III subunit I
    Names
    CG4875-PB
    CG4875-PC
    Polr3I-PB
    Polr3I-PC
    receptor component protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16884581..16886612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132947.5 → NP_573175.2  RNA polymerase III subunit I, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573175.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SV49, Q7KUX1, Q9VX99
      Conserved Domains (1) summary
      pfam03874
      Location:10 → 112
      RNA_pol_Rpb4; RNA polymerase Rpb4

    2. NM_206770.2 → NP_996493.1  RNA polymerase III subunit I, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996493.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SV49, Q7KUX1, Q9VX99
      Conserved Domains (1) summary
      pfam03874
      Location:10 → 112
      RNA_pol_Rpb4; RNA polymerase Rpb4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K1S9 Q7K1S9
    Q9VX99 Q9VX99

    Gene LinkOut

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