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    CG4239 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32606, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CG4239provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030745
    Locus tag
    Dmel_CG4239
    See related
    AllianceGenome:FB:FBgn0030745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4239
    Summary
    Predicted to enable potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in sarcoplasmic reticulum. Is expressed in adult head; adult heart; indirect flight muscle cell; larval muscle system; and larval somatic muscle cell. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 14. Orthologous to human TMEM38A (transmembrane protein 38A) and TMEM38B (transmembrane protein 38B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See CG4239 in Genome Data Viewer
    Location:
    14C2-14C2; 1-53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16385278..16388702)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16279311..16282735)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Furin 2 Neighboring gene uncharacterized protein Neighboring gene TH1 Neighboring gene meiotic 41 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of miRNA-9 Generates Muscle Hypercontraction Through Translational Repression of Troponin-T in Drosophila melanogaster Indirect Flight Muscles. Katti P, et al. G3 (Bethesda), 2017 Oct 5. PMID 28866639, Free PMC Article
    2. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Dutta D, et al. Proc Natl Acad Sci U S A, 2024 Feb 27. PMID 38381787, Free PMC Article
    3. Analysis of Ras-induced overproliferation in Drosophila hemocytes. Asha H, et al. Genetics, 2003 Jan. PMID 12586708, Free PMC Article
    4. Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet. Çiçek IÖ, et al. Genetics, 2016 Mar. PMID 26801178, Free PMC Article
    5. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sarcoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4239-PA
    CG4239-PB
    CG4239-PC
    CG4239-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16385278..16388702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167515.2 → NP_727972.1  uncharacterized protein Dmel_CG4239, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727972.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXG9
      Related
      FBpp0074044
      Conserved Domains (1) summary
      pfam05197
      Location:42 → 226
      TRIC; TRIC channel

    2. NM_132894.3 → NP_573122.1  uncharacterized protein Dmel_CG4239, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573122.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXG9
      Related
      FBpp0074045
      Conserved Domains (1) summary
      pfam05197
      Location:42 → 226
      TRIC; TRIC channel

    3. NM_167516.2 → NP_727973.1  uncharacterized protein Dmel_CG4239, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727973.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXG9
      Related
      FBpp0074046
      Conserved Domains (1) summary
      pfam05197
      Location:42 → 226
      TRIC; TRIC channel

    4. NM_001298396.1 → NP_001285325.1  uncharacterized protein Dmel_CG4239, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285325.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXG9
      Conserved Domains (1) summary
      pfam05197
      Location:42 → 226
      TRIC; TRIC channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXG9 Q9VXG9

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