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    CalpC Calpain C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32597, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CalpCprovided by FlyBase
    Official Full Name
    Calpain Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260450
    Locus tag
    Dmel_CG3692
    See related
    AllianceGenome:FB:FBgn0260450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3692; Dmel\CG3692
    Old locus tag
    CG3692
    Summary
    Predicted to enable calcium ion binding activity. Located in cytoplasm. Is expressed in embryonic/larval salivary gland and organism. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; eosinophilic esophagitis; and muscular dystrophy. Orthologous to human CAPN13 (calpain 13); CAPN14 (calpain 14); and CAPN3 (calpain 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See CalpC in Genome Data Viewer
    Location:
    14B13-14B13; 1-53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16325763..16328523)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16219796..16222556)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Strumpellin and WASH-interacting protein Neighboring gene Cyclophilin 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dorsal switch protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and RNA expression of a novel Drosophila calpain, Calpain C. Spadoni C, et al. Biochem Biophys Res Commun, 2003 Mar 28. PMID 12646209
    2. The intriguing Ca2+ requirement of calpain activation. Friedrich P. Biochem Biophys Res Commun, 2004 Oct 29. PMID 15451413
    3. The calpain-system of Drosophila melanogaster: coming of age. Friedrich P, et al. Bioessays, 2004 Oct. PMID 15382138
    4. The Ca2+-dependent protease Calpain A regulates Cactus/I kappaB levels during Drosophila development in response to maternal Dpp signals. Fontenele M, et al. Mech Dev, 2009 Aug-Sep. PMID 19442719
    5. Requirement for and polarized localization of integrin proteins during Drosophila wound closure. Park SH, et al. Mol Biol Cell, 2018 Sep 1. PMID 29995573, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables calcium-dependent cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables calcium-dependent cysteine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in proteolysis IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT involved_in proteolysis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calpain C
    Names
    CG3692-PA
    CalpC-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16325763..16328523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132890.3 → NP_573118.2  calpain C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573118.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86NA1, Q95R89, Q9VXH6
      UniProtKB/TrEMBL
      T2GFF8
      Related
      FBpp0074005
      Conserved Domains (3) summary
      COG5126
      Location:567 → 648
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00044
      Location:7 → 329
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd00214
      Location:346 → 483
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXH6.4 Q9VXH6

    Gene LinkOut

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    Other Literature Sources
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