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    Prp5 pre-mRNA processing factor 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32464, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Prp5provided by FlyBase
    Official Full Name
    pre-mRNA processing factor 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0030631
    Locus tag
    Dmel_CG6227
    See related
    AllianceGenome:FB:FBgn0030631
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg6227; CG6227; Dmel\CG6227; DmRH29
    Summary
    Predicted to enable RNA helicase activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be part of spliceosomal complex. Predicted to be active in nucleus. Is expressed in adult head. Orthologous to human DDX46 (DEAD-box helicase 46). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Prp5 in Genome Data Viewer
    Location:
    13B7-13B8; 1-50 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15345169..15350021)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15239202..15244054)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene abnormal chemosensory jump 6 Neighboring gene Protein phosphatase 1 at 13C Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recent strong positive selection on Drosophila melanogaster HDAC6, a gene encoding a stress surveillance factor, as revealed by population genomic analysis. Svetec N, et al. Mol Biol Evol, 2009 Jul. PMID 19349642
    2. Changes in gene expression linked with adult reproductive diapause in a northern malt fly species: a candidate gene microarray study. Kankare M, et al. BMC Ecol, 2010 Feb 1. PMID 20122138, Free PMC Article
    3. Identification of novel Drosophila centromere-associated proteins. Barth TK, et al. Proteomics, 2014 Oct. PMID 24841622
    4. The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. Abramczuk MK, et al. Development, 2017 Nov 1. PMID 28935704
    5. Comprehensive analysis of nucleocytoplasmic dynamics of mRNA in Drosophila cells. Chen T, et al. PLoS Genet, 2017 Aug. PMID 28771467, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pre-mRNA processing factor 5
    Names
    CG6227-PA
    Prp5-PA
    NP_573020.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15345169..15350021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132792.3 → NP_573020.2  pre-mRNA processing factor 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573020.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5I7A3, C5I7B1, C5I7H5, Q9VXW2
      Related
      FBpp0073828
      Conserved Domains (3) summary
      COG0513
      Location:482 → 967
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00079
      Location:733 → 860
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:516 → 719
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TU3 Q95TU3
    Q9VXW2 Q9VXW2

    Gene LinkOut

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