U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    amrt amaretto [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32342, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    amrtprovided by FlyBase
    Official Full Name
    amarettoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030522
    Locus tag
    Dmel_CG11103
    See related
    AllianceGenome:FB:FBgn0030522
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LP03404; CG11103; Dmel\CG11103
    Summary
    Involved in positive regulation of Notch signaling pathway. Predicted to be located in plasma membrane. Is expressed in organism. Used to study Alzheimer's disease. Orthologous to human TM2D2 (TM2 domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See amrt in Genome Data Viewer
    Location:
    12C4-12C4; 1-46 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13782459..13783381)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13676492..13677414)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene retinal degeneration B Neighboring gene Cathepsin B Neighboring gene inactivation no afterpotential E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Functional unknomics: Systematic screening of conserved genes of unknown function. Rocha JJ, et al. PLoS Biol, 2023 Aug. PMID 37552676, Free PMC Article
    2. TM2D genes regulate Notch signaling and neuronal function in Drosophila. Salazar JL, et al. PLoS Genet, 2021 Dec. PMID 34905536, Free PMC Article
    3. Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits. Godfrey RK, et al. Acta Neuropathol Commun, 2023 Oct 20. PMID 37864255, Free PMC Article
    4. Human Diseases Associated with Notch Signalling: Lessons from Drosophila melanogaster. Megaly M, et al. Front Biosci (Landmark Ed), 2024 Jun 25. PMID 38940046
    5. An RNAi-mediated screen identifies novel targets for next-generation antiepileptic drugs based on increased expression of the homeostatic regulator pumilio. Lin WH, et al. J Neurogenet, 2018 Mar-Jun. PMID 29718742, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TM2D genes regulate Notch signaling and neuronal function in Drosophila.
      Title: TM2D genes regulate Notch signaling and neuronal function in Drosophila.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in positive regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    amaretto
    Names
    CG11103-PC
    amrt-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13782459..13783381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038753.2 → NP_001033842.2  amaretto [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VY86
      Conserved Domains (1) summary
      pfam05154
      Location:156 → 205
      TM2; TM2 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VY86.3 Q9VY86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools