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    gtf2h2 general transcription factor IIH, polypeptide 2 [ Danio rerio (zebrafish) ]

    Gene ID: 323239, updated on 17-Aug-2024

    Summary

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    Official Symbol
    gtf2h2provided by ZNC
    Official Full Name
    general transcription factor IIH, polypeptide 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1959
    See related
    Ensembl:ENSDARG00000016514 AllianceGenome:ZFIN:ZDB-GENE-030131-1959
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb93b01
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in nucleotide-excision repair and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within DNA repair and transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIH holo complex. Orthologous to several human genes including GTF2H2C (GTF2H2 family member C). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (26221011..26233068)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (25620858..25632915)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene MARVEL domain containing 2b Neighboring gene occludin b Neighboring gene endoplasmic reticulum aminopeptidase 1b Neighboring gene N-acetylated alpha-linked acidic dipeptidase like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Activation of the nucleotide excision repair pathway by crude oil exposure: A translational study from model organisms to the Hebei Spirit Oil Spill Cohort. Kim Y, et al. Environ Pollut, 2019 Nov. PMID 31454576
    2. Evolutionary conservation of TFIIH subunits: implications for the use of zebrafish as a model to study TFIIH function and regulation. Silva IA, et al. Comp Biochem Physiol B Biochem Mol Biol, 2014 Jun-Jul. PMID 24731924
    3. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor IIH subunit 2
    Names
    general transcription factor IIH, polypeptide 2, 44kDa
    p44

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201581.1 → NP_963875.1  general transcription factor IIH subunit 2

      See identical proteins and their annotated locations for NP_963875.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045397
      UniProtKB/TrEMBL
      A0A8M1PCN9, Q7ZVV4
      Related
      ENSDARP00000018901.6, ENSDART00000007587.7
      Conserved Domains (2) summary
      cd01453
      Location:56 → 240
      vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...
      cl06838
      Location:288 → 385
      C1_4; TFIIH C1-like domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      26221011..26233068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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