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    wsb1 WD repeat and SOCS box containing 1 [ Danio rerio (zebrafish) ]

    Gene ID: 323226, updated on 2-Nov-2024

    Summary

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    Official Symbol
    wsb1provided by ZNC
    Official Full Name
    WD repeat and SOCS box containing 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1946
    See related
    Ensembl:ENSDARG00000021343 AllianceGenome:ZFIN:ZDB-GENE-030131-1946
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63905; wu:fb92g11
    Summary
    Predicted to be involved in protein polyubiquitination. Predicted to act upstream of or within intracellular signal transduction. Is expressed in several structures, including digestive system; eye; fin; heart; and spleen. Orthologous to human WSB1 (WD repeat and SOCS box containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See wsb1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (31161783..31177270, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (31281042..31296606, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene lectin, galactoside-binding, soluble, 9 (galectin 9)-like 3 Neighboring gene kinase suppressor of ras 1b Neighboring gene CUE domain containing 1b Neighboring gene vascular endothelial zinc finger 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of WSB1 gene as an important regulator in the development of zebrafish embryo during midblastula transition. Lv W, et al. Acta Biochim Biophys Sin (Shanghai), 2008 Jun. PMID 18535746
    2. Characterization of a BAC library from channel catfish Ictalurus punctatus: indications of high levels of chromosomal reshuffling among teleost genomes. Wang S, et al. Mar Biotechnol (NY), 2007 Nov-Dec. PMID 17671813
    3. Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Zhang P, et al. Cell Rep, 2014 Mar 27. PMID 24613356
    4. Galectins in channel catfish, Ictalurus punctatus: Characterization and expression profiling in mucosal tissues. Zhou S, et al. Fish Shellfish Immunol, 2016 Feb. PMID 26767746
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat and SOCS box-containing protein 1
    Names
    SOCS box-containing WD protein SWiP-1
    WSB-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199633.1 → NP_955927.1  WD repeat and SOCS box-containing protein 1

      See identical proteins and their annotated locations for NP_955927.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054567
      UniProtKB/Swiss-Prot
      Q7T2F6
      Related
      ENSDARP00000005989.4, ENSDART00000008854.5
      Conserved Domains (4) summary
      COG2319
      Location:38 → 379
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:136 → 379
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd03746
      Location:383 → 422
      SOCS_WSB1_SWIP1; SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 ...
      sd00039
      Location:135 → 169
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      31161783..31177270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7T2F6.1 GenPept UniProtKB/Swiss-Prot:Q7T2F6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.