wrap53 WD repeat containing, antisense to TP53 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wrap53provided by ZNC
Official Full Name: WD repeat containing, antisense to TP53provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-515
See related: Ensembl:ENSDARG00000086150 AllianceGenome:ZFIN:ZDB-GENE-030131-515
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb34f12; fi26g08; wu:fb34f12; wu:fi26g08
Summary: Predicted to enable RNA binding activity. Predicted to be involved in Cajal body organization. Predicted to be active in Cajal body. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 3; colorectal cancer; head and neck squamous cell carcinoma; lung non-small cell carcinoma; and ovarian cancer. Orthologous to human WRAP53 (WD repeat containing antisense to TP53). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (20917964..20940213)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (20651599..20673875)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi26g08.x1 (e-PCR)
- UniSTS:197138

fb34f12.x1 (e-PCR)
- UniSTS:203137

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Cajal body organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Cajal body	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: telomerase Cajal body protein 1

Names: WD repeat domain 79

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256028.1 → NP_001242957.1 telomerase Cajal body protein 1

See identical proteins and their annotated locations for NP_001242957.1

Status: VALIDATED

Source sequence(s)

CR388099

UniProtKB/TrEMBL

A0A8M1P3C1, E7F3D5

Related

ENSDARP00000105980.1, ENSDART00000129161.4

Conserved Domains (3) summary

COG2319
Location:160 → 478

WD40; WD40 repeat [General function prediction only]

sd00039
Location:166 → 210

7WD40; WD40 repeat [structural motif]

cl02567
Location:160 → 474

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

20917964..20940213

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005172209.5 → XP_005172266.1 telomerase Cajal body protein 1 isoform X1

See identical proteins and their annotated locations for XP_005172266.1

UniProtKB/TrEMBL

A0A8M1P3C1, E7F3D5

Conserved Domains (3) summary

COG2319
Location:160 → 478

WD40; WD40 repeat [General function prediction only]

sd00039
Location:166 → 210

7WD40; WD40 repeat [structural motif]

cl02567
Location:160 → 474

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...