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    Antdh Antennal dehydrogenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32058, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Antdhprovided by FlyBase
    Official Full Name
    Antennal dehydrogenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026268
    Locus tag
    Dmel_CG1386
    See related
    AllianceGenome:FB:FBgn0026268
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    antdh; AntDH; CG1386; Dmel\CG1386; FOHSDR
    Summary
    Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be located in cytoplasm. Is expressed in adult head and third segment of antenna. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Antdh in Genome Data Viewer
    Location:
    10A10-10A10; 1-33 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11168030..11169058, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11062063..11063091, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene l(3)mbt interacting protein 1 Neighboring gene retroactive Neighboring gene Dynein light intermediate chain Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preferential expression of biotransformation enzymes in the olfactory organs of Drosophila melanogaster, the antennae. Wang Q, et al. J Biol Chem, 1999 Apr 9. PMID 10187818
    2. Retroactive, a membrane-anchored extracellular protein related to vertebrate snake neurotoxin-like proteins, is required for cuticle organization in the larva of Drosophila melanogaster. Moussian B, et al. Dev Dyn, 2005 Jul. PMID 15844167
    3. The early developmental gene Semaphorin 5c contributes to olfactory behavior in adult Drosophila. Rollmann SM, et al. Genetics, 2007 Jun. PMID 17435226, Free PMC Article
    4. Molecular Profiling of the Drosophila Antenna Reveals Conserved Genes Underlying Olfaction in Insects. Mohapatra P, et al. G3 (Bethesda), 2019 Nov 5. PMID 31527046, Free PMC Article
    5. A high-fat diet impacts memory and gene expression of the head in mated female Drosophila melanogaster. Rivera O, et al. J Comp Physiol B, 2019 Apr. PMID 30810797, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 17-beta-ketosteroid reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 3-keto sterol reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    antennal dehydrogenase
    Names
    Antdh-PA
    CG1386-PA
    antdh
    NP_572695.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11168030..11169058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132467.3 → NP_572695.2  antennal dehydrogenase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572695.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SY92, Q9VZ19
      Related
      FBpp0073324
      Conserved Domains (2) summary
      COG4221
      Location:1 → 250
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
      cl21454
      Location:1 → 245
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SY92 Q8SY92
    Q9VZ19 Q9VZ19
    Q9XYN2 Q9XYN2

    Gene LinkOut

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