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    CG2124 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31989, updated on 10-May-2024

    Summary

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    Official Symbol
    CG2124provided by FlyBase
    Primary source
    FLYBASE:FBgn0030217
    Locus tag
    Dmel_CG2124
    See related
    AllianceGenome:FB:FBgn0030217
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2124
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial RNA processing and regulation of mitochondrial mRNA stability. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Is expressed in spermatozoon. Orthologous to human FASTKD5 (FAST kinase domains 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG2124 in Genome Data Viewer
    Location:
    9D3-9D4; 1-32 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10596122..10599169)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10490155..10493202)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rab at 9D Neighboring gene Hybrid male rescue Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rab at 9Db

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recurrent positive selection of the Drosophila hybrid incompatibility gene Hmr. Maheshwari S, et al. Mol Biol Evol, 2008 Nov. PMID 18755760, Free PMC Article
    2. Reduced fertility of Drosophila melanogaster hybrid male rescue (Hmr) mutant females is partially complemented by Hmr orthologs from sibling species. Aruna S, et al. Genetics, 2009 Apr. PMID 19153254, Free PMC Article
    3. RAP--a putative RNA-binding domain. Lee I, et al. Trends Biochem Sci, 2004 Nov. PMID 15501674
    4. Functional divergence caused by ancient positive selection of a Drosophila hybrid incompatibility locus. Barbash DA, et al. PLoS Biol, 2004 Jun. PMID 15208709, Free PMC Article
    5. A rapidly evolving MYB-related protein causes species isolation in Drosophila. Barbash DA, et al. Proc Natl Acad Sci U S A, 2003 Apr 29. PMID 12695567, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2124-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10596122..10599169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132410.3 → NP_572638.1  uncharacterized protein Dmel_CG2124 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572638.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86CW0, Q9W2T3
      Related
      FBpp0071420
      Conserved Domains (1) summary
      smart00952
      Location:565 → 622
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86CW0 Q86CW0
    Q86CW2 Q86CW2
    Q9W2T3 Q9W2T3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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