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    mAChR-C muscarinic Acetylcholine Receptor, C-type [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31626, updated on 4-Jul-2024

    Summary

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    Official Symbol
    mAChR-Cprovided by FlyBase
    Official Full Name
    muscarinic Acetylcholine Receptor, C-typeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029909
    Locus tag
    Dmel_CG12796
    See related
    AllianceGenome:FB:FBgn0029909
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12796; Dmel\CG12796
    Summary
    Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled acetylcholine receptor signaling pathway. Predicted to be integral component of membrane. Is expressed in adult head. Orthologous to human GPR119 (G protein-coupled receptor 119). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See mAChR-C in Genome Data Viewer
    Location:
    6D4-6D4; 1-18 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6831397..6832684, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6725430..6726717, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene xiantuan Neighboring gene Ataxin 1 Neighboring gene no-on-and-no-off transient C Neighboring gene uncharacterized protein Neighboring gene TATA element modulatory factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localization of muscarinic acetylcholine receptor-dependent rhythm-generating modules in the Drosophila larval locomotor network. Jonaitis J, et al. J Neurophysiol, 2022 Apr 1. PMID 35294308, Free PMC Article
    2. Pharmacological identification of cholinergic receptor subtypes: modulation of locomotion and neural circuit excitability in Drosophila larvae. Malloy CA, et al. Neuroscience, 2019 Jul 15. PMID 31102763
    3. The neurobiology and evolution of cannabinoid signalling. Elphick MR, et al. Philos Trans R Soc Lond B Biol Sci, 2001 Mar 29. PMID 11316486, Free PMC Article
    4. A new family of insect muscarinic acetylcholine receptors. Xia RY, et al. Insect Mol Biol, 2016 Aug. PMID 27003873
    5. Muscarinic acetylcholine receptor activation synergizes the knockdown and toxicity of GABA-gated chloride channel insecticides. Xie N, et al. Pest Manag Sci, 2022 Nov. PMID 35841135, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled acetylcholine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled amine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    muscarinic acetylcholine Receptor, C-type
    Names
    CG12796-PA
    mAChR-C-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6831397..6832684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132130.2 → NP_572358.1  muscarinic acetylcholine Receptor, C-type [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572358.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A109NH66, Q9W3V5
      Related
      FBpp0070934
      Conserved Domains (2) summary
      pfam00001
      Location:67 → 321
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:61 → 332
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3V5 Q9W3V5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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