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    Rbcn-3A Rabconnectin-3A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31557, updated on 10-May-2024

    Summary

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    Official Symbol
    Rbcn-3Aprovided by FlyBase
    Official Full Name
    Rabconnectin-3Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023458
    Locus tag
    Dmel_CG3585
    See related
    AllianceGenome:FB:FBgn0023458
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-X; CG3585; Dmel\CG3585; Dmx; DmX; FV10; rbcn3A; X
    Summary
    Involved in lumen formation, open tracheal system and vacuolar acidification. Predicted to be part of RAVE complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 71 and developmental and epileptic encephalopathy 81. Orthologous to human DMXL1 (Dmx like 1) and DMXL2 (Dmx like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See Rbcn-3A in Genome Data Viewer
    Location:
    5E1-5E3; 1-16 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6240745..6255487, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6134778..6149520, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene detonator Neighboring gene uncharacterized protein Neighboring gene schlank Neighboring gene Spliceosomal protein on the X Neighboring gene Josephin domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intracellular lumen formation in Drosophila proceeds via a novel subcellular compartment. Nikolova LS, et al. Development, 2015 Nov 15. PMID 26428009, Free PMC Article
    2. Enhanced nucleotide chemistry and toehold nanotechnology reveals lncRNA spreading on chromatin. Machyna M, et al. Nat Struct Mol Biol, 2020 Mar. PMID 32157249
    3. The new gene DmX from Drosophila melanogaster encodes a novel WD-repeat protein. Kraemer C, et al. Gene, 1998 Aug 31. PMID 9729422
    4. A fluorescent tagging approach in Drosophila reveals late endosomal trafficking of Notch and Sanpodo. Couturier L, et al. J Cell Biol, 2014 Nov 10. PMID 25365996, Free PMC Article
    5. Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain. Wang M, et al. Nat Commun, 2021 Apr 7. PMID 33828096, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in lumen formation, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RAVE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rabconnectin-3A
    Names
    CG3585-PB
    Rabconnectin-3alpha
    Rbcn-3A-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6240745..6255487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132074.3 → NP_572302.2  Rabconnectin-3A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572302.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24593, Q9W425
      Conserved Domains (4) summary
      COG2319
      Location:3153 → 3373
      WD40; WD40 repeat [General function prediction only]
      pfam12234
      Location:1643 → 2134
      Rav1p_C; RAVE protein 1 C terminal
      sd00039
      Location:3203 → 3243
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:3158 → 3412
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24593 Q24593
    Q9W425 Q9W425

    Gene LinkOut

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