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    CHOp24 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31382, updated on 10-May-2024

    Summary

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    Official Symbol
    CHOp24provided by FlyBase
    Primary source
    FLYBASE:FBgn0029709
    Locus tag
    Dmel_CG3564
    See related
    AllianceGenome:FB:FBgn0029709
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3564; Dmel\CG3564; emp24; Emp24; p24; p24/p24beta1
    Summary
    Enables cargo receptor activity. Involved in Wnt protein secretion; endoplasmic reticulum to Golgi vesicle-mediated transport; and wing disc development. Located in endomembrane system. Is expressed in several structures, including anterior endoderm anlage; egg chamber; embryonic/larval midgut primordium; endoderm; and gut section. Orthologous to human TMED2 (transmembrane p24 trafficking protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See CHOp24 in Genome Data Viewer
    Location:
    4C7-4C7; 1-8 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4540908..4542506)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4434941..4436539)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR32773 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ruby Neighboring gene Usf

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila p24 and Sec22 regulate Wingless trafficking in the early secretory pathway. Li X, et al. Biochem Biophys Res Commun, 2015 Aug 7. PMID 26002470, Free PMC Article
    2. Drosophila Cornichon acts as cargo receptor for ER export of the TGFalpha-like growth factor Gurken. Bökel C, et al. Development, 2006 Feb. PMID 16396907
    3. p24 family proteins: key players in the regulation of trafficking along the secretory pathway. Pastor-Cantizano N, et al. Protoplasma, 2016 Jul. PMID 26224213
    4. Drosophila melanogaster p24 genes have developmental, tissue-specific, and sex-specific expression patterns and functions. Boltz KA, et al. Dev Dyn, 2007 Feb. PMID 17131401
    5. p24 proteins, intracellular trafficking, and behavior: Drosophila melanogaster provides insights and opportunities. Carney GE, et al. Biol Cell, 2004 May. PMID 15145531

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Emp24 and Eca act as specific cargo receptors for Wg to concentrate it in forming vesicles at sites of endoplasmic reticulum export.
      Title: A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cargo receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cargo receptor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi vesicle transport ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CHOp24
    Names
    CG3564-PA
    CG3564-PB
    CHOp24-PA
    CHOp24-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4540908..4542506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297933.1 → NP_001284862.1  CHOp24, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284862.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W4K0
      Conserved Domains (1) summary
      pfam01105
      Location:24 → 203
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD

    2. NM_131937.4 → NP_572165.1  CHOp24, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572165.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W4K0
      Related
      FBpp0070643
      Conserved Domains (1) summary
      pfam01105
      Location:24 → 203
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W4K0 Q9W4K0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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