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    Rbm12b RNA binding motif protein 12B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313069, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Rbm12bprovided by RGD
    Official Full Name
    RNA binding motif protein 12Bprovided by RGD
    Primary source
    RGD:1307658
    See related
    EnsemblRapid:ENSRNOG00000016330 AllianceGenome:RGD:1307658
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307658
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Orthologous to human RBM12B (RNA binding motif protein 12B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 83.3), Thymus (RPKM 81.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbm12b in Genome Data Viewer
    Location:
    5q13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (30394756..30507428)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (25597405..25610324)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (25247990..25257678)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene RNA-binding protein 12B-A-like Neighboring gene transmembrane protein 67 Neighboring gene CBY1 interacting BAR domain containing 1 Neighboring gene uncharacterized LOC120102833 Neighboring gene triple QxxK/R motif containing Neighboring gene transfer RNA threonine (anticodon AGU) 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 12B
    Names
    RNA-binding protein 12B-A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408811.1 → NP_001395740.1  RNA-binding protein 12B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2JYP3, D3ZM54
      Related
      ENSRNOP00000058050.3, ENSRNOT00000061333.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      30394756..30507428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110939.2 → XP_038966867.1  RNA-binding protein 12B isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYP3, D3ZM54
      Conserved Domains (5) summary
      PTZ00465
      Location:619 → 703
      PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
      COG0724
      Location:367 → 581
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12746
      Location:152 → 237
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:401 → 476
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cl17169
      Location:2 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_039110940.2 → XP_038966868.1  RNA-binding protein 12B isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYP3, D3ZM54
      Conserved Domains (5) summary
      PTZ00465
      Location:619 → 703
      PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
      COG0724
      Location:367 → 581
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12746
      Location:152 → 237
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:401 → 476
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cl17169
      Location:2 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_063287576.1 → XP_063143646.1  RNA-binding protein 12B isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYP3, D3ZM54

    4. XM_039110943.2 → XP_038966871.1  RNA-binding protein 12B isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYP3, D3ZM54
      Conserved Domains (5) summary
      PTZ00465
      Location:619 → 703
      PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
      COG0724
      Location:367 → 581
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12746
      Location:152 → 237
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:401 → 476
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cl17169
      Location:2 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. XM_063287578.1 → XP_063143648.1  RNA-binding protein 12B isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYP3, D3ZM54

    6. XM_063287577.1 → XP_063143647.1  RNA-binding protein 12B isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYP3, D3ZM54
    Nucleotide Protein Strain
    Heading Accession and Version

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