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    Grp170 Grp170 co-chaperone [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31215, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Grp170provided by FlyBase
    Official Full Name
    Grp170 co-chaperoneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023529
    Locus tag
    Dmel_CG2918
    See related
    AllianceGenome:FB:FBgn0023529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2918; CT9894; Dmel\CG2918; EG:25E8.1; GRP170
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in cellular response to hypoxia and negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. Located in extracellular space. Is expressed in several structures, including circulatory system; early extended germ band embryo; embryonic epidermis; gut section; and trunk ectoderm. Human ortholog(s) of this gene implicated in immunodeficiency 59. Orthologous to human HYOU1 (hypoxia up-regulated 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Grp170 in Genome Data Viewer
    Location:
    2F3-2F4; 1-0.9 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2271008..2275068, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2165041..2169101, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45480 Neighboring gene Vitelline membrane-like Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The hsp110 and Grp1 70 stress proteins: newly recognized relatives of the Hsp70s. Easton DP, et al. Cell Stress Chaperones, 2000 Oct. PMID 11048651, Free PMC Article
    2. Enrichment of O-GlcNAc modified proteins by the periodate oxidation-hydrazide resin capture approach. Klement E, et al. J Proteome Res, 2010 May 7. PMID 20146544, Free PMC Article
    3. The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder. Williams MJ, et al. PLoS Genet, 2016 Jun. PMID 27280443, Free PMC Article
    4. Differences in Postmating Transcriptional Responses between Conspecific and Heterospecific Matings in Drosophila. Ahmed-Braimah YH, et al. Mol Biol Evol, 2021 Mar 9. PMID 33035303, Free PMC Article
    5. Proteomic identification of Drosophila melanogaster male accessory gland proteins, including a pro-cathepsin and a soluble gamma-glutamyl transpeptidase. Walker MJ, et al. Proteome Sci, 2006 May 2. PMID 16670001, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    part_of endoplasmic reticulum chaperone complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Grp170 co-chaperone
    Names
    CG2918-PA
    CG2918-PB
    Grp170-PA
    Grp170-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2271008..2275068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169174.2 → NP_001162645.1  Grp170 co-chaperone, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162645.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46067
      Conserved Domains (3) summary
      cd10230
      Location:23 → 409
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      pfam00012
      Location:22 → 625
      HSP70; Hsp70 protein
      cl05005
      Location:572 → 627
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    2. NM_130639.4 → NP_569995.1  Grp170 co-chaperone, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569995.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46067
      Related
      FBpp0070395
      Conserved Domains (3) summary
      cd10230
      Location:23 → 409
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      pfam00012
      Location:22 → 625
      HSP70; Hsp70 protein
      cl05005
      Location:572 → 627
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46067 O46067

    Gene LinkOut

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